Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-06-14
2011-06-14
Swartz, Rodney P. (Department: 1645)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C424S009100, C424S009200, C424S184100, C424S185100, C424S192100, C424S200100
Reexamination Certificate
active
07960535
ABSTRACT:
The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterologous leader sequence derived from the ospA gene ofBorrelia burgdorferi, which leader sequence is joined in translational reading frame with the psaA structural gene. The invention also provides methods of preparation of lipidated PsaA proteins and use of such proteins in immunological compositions. Also provided are vaccines comprising immunogenic lipidated PsaA proteins and methods of use of such vaccines in the prevention and treatment ofS. pneumoniaeinfection.
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Ades Edwin W.
Carlone George M.
De Barun K.
Huebner Robert C.
Sampson Jacquelyn S.
Klarquist & Sparkman, LLP
Swartz Rodney P.
The United States of America as represented by the Department of
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