Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1998-04-14
1999-01-26
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
43525233, 435232, 43525411, 435325, 435410, 4353201, 536 232, 935 22, C12N 120, C12N 1500, C12N 988, C07H 2104
Patent
active
058637885
ABSTRACT:
A recombinant protein capable of constituting a recombinant L-methionine .gamma.-lyase or a variant thereof, a recombinant oligomeric enzyme, preferably tetrameric enzyme, consisting of the recombinant protein, a DNA molecule encoding the same, an expression vector containing the DNA molecule, a host cell harboring the expression vector, a method of preparing the recombinant L-methionine .gamma.-lyase, and anti-tumor agent comprising the recombinant L-methionine .gamma.-lyase or a variant thereof are provided.
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Nippon Nogeikagaku Kaisha, 68, p. 106 (Mar. 3, 1994).
Nayakama et al., Purification of Bacterial L-Methionine gamma-Lyase, Analytical Biochemistry 138: 421-424, (1984).
Erickson et al., Sequence of cDNA for rat cystathionine gamma-lyase and comparison of deduced amino acid sequence with related Escherichia coli enzymes, Biochemical Journal 269:335-340, (1990).
Rudinger, J. Characteristics of the amino acids as components of a peptide hormone sequence, In Peptide Hormones, Ed. J. A. Parsons, University Park Press, pp. 1-7 (1976).
Thornton et al., Protein Engineering: Editorial Overview, Current Opinion in Biotechnology 6(4): 367-369, (1995).
Ngo et al., Computational complexity, protein structure prediction, and the 1levinthal paradox. In: The Protein Folding Problem and Tertiary Structure Prediction. Eds. Merz et al. Birkhauser et al. Boston, MA, pp. 491-495 (1994).
Wallace, Understanding cytochrome c function: engineering protein structure by semisynthesis. The FASEB Journal 7: 505-515 (1993).
Esaki Nobuyoshi
Inagaki Kenji
Inoue Hiroyuki
Soda Kenji
Sugimoto Manabu
Shionogi & Co. Ltd.
Stole Einar
Wax Robert A.
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