Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2003-10-07
2009-12-01
Steadman, David J (Department: 1656)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C536S023100
Reexamination Certificate
active
07625735
ABSTRACT:
A recombinantDrosophila melanogasterdeoxynucleoside kinase that remains stable during the synthesis of nucleoside monophosphate without the addition of stabilizing SH reagents or stabilizing proteins, and that accepts all four natural deoxynucleotides is provided. In addition, the invention concerns DNA sequences, vectors, transformed cells, a method for production of the recombinant kinase as well as its use for preparing nucleoside monophosphates.
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Munch-Petersen, B., Piskur, J., Sondergaard, L. “Four Deoxynucleoside Kinase Activities from Drosophila melanogaster Are Contained within a Single Monomeric Enzyme, a New Multifunctional Deoxynucleoside Kinase.” The Journal of Biological Chemistry, vol. 273, No. 7, Feb. 13, 1998, pp. 3926-2931.
Ihlenfeldt Hans-Georg
Munch-Petersen Brigitte
Piskur Jure
Sondergaard Leif
Barnes & Thornburg LLP
Kim Alexander D
Roche Diagnostic Operations, Inc.
Steadman David J
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