Recombinant kat enzyme from rat

Details Recombinant kat enzyme from rat Recombinant kat enzyme from rat

1994-07-07

1998-10-06

Hendricks, Keith D.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

536 232, C12N 910

Patent

active

058174966

ABSTRACT:
Disclosed are isolated DNAs encoding a kynurenine aminotransferase selected from the group consisting of: (a) an isolated DNA sequence which encodes rat KAT; (b) an isolated DNA sequence which hybridizes to the isolated DNA sequence of (a) above and which encodes a KAT enzyme; and (c) an isolated DNA sequence differing from the isolated DNA sequences of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a KAT enzyme. Also disclosed are vectors and host cells containing the same; oligonucleotide probes for identifying kynurenine aminotransferase; and isolated and purified kynurenine aminotransferase.

REFERENCES:
Mosca et al, "Molecular Cloning of Rat Kynurenine Aminotransferase: Identity With Glutamine Transaminase K", FEBS Letter, 353:21-24 (1994).
Baran et al., J. Neurochem. vol. 62, pp. 730-738, 1994.
Asada et al., J. Biochem., 99:1101-1110, 1986.
Mawal et al., J. Biochem. 279:595-599, 1991.
Takeuchi et al., Biochem. Biophys. Acta, 743:323-330, 1983.

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