Recombinant insect virus with reduced capacity for host-to-host

Details Recombinant insect virus with reduced capacity for host-to-host Recombinant insect virus with reduced capacity for host-to-host

1993-05-28

2000-10-10

Guzo, David

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

4352351, 4353201, 435325, 435348, 435 9142, 435 914, C12N 1563, C12N 1564, C12N 15866, C12N 510

Patent

active

061300748

ABSTRACT:
A noninfectious insect virus is described having an altered genetic element whose function is restored by genetic complementation, thereby again producing the insect infectious form of the virus. Also described is the insertion of a heterologous gene into the viral genome, such that an insect controlling or modifying substance is also produced by the virus for an improved bioinsecticidal effect and genetic stability of desired traits.

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Werstuck et al. "Enhanced Infectivity of Herpes Simplex Virus Type 1 Viral DNA in a Cell Line Expressing the trans-Inducing Factor Vmw 65" Journal of Virology, Mar. 1990, vol. 64, No. 3, pp. 984-991.
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Winstanley, D., et al., J. gen. Virol., 74, 1599-1609 (1993).
Burand, J., et al., Sequence Analysis of the Gypsy Moth Virus Virulence Gene, p77, Proceedings U.S. Department of Agriculture Interagency Gypsy Moth Research Forum 1992, Annapolis, MD (Jan. 13-16, 1992).
Hill, J. E., et al., Biochim. et Biophys. Acta, 1172, 187-189 (1993).

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