Recombinant infectious laryngotracheitis virus

Details Recombinant infectious laryngotracheitis virus Recombinant infectious laryngotracheitis virus

1991-04-05

1994-01-18

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Vector, per se

435 691, 4351723, 4352402, C12N 1586, C12N 510

Patent

active

052799654

ABSTRACT:
The present invention is concerned with the preparation of an Infectious Laryngotracheitis Virus (ILTV) mutant which does not produce a functional thymidine kinase enzyme as a result of a mutation in the TK gene, and its preparation.
The invention also relates to an ILTV mutant containing a heterologous gene encoding an antigen of an avian pathogen incorporated into the TK gene. Such an ILTV mutant can be applied as a vector vaccine to induce an immune response after infection of an appropriate host animal.

REFERENCES:
patent: 4980162 (1990-12-01), Honda et al.
Griffin et al., Journal of General Virology, vol. 71, pp. 841-850 (1990).

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