Recombinant infectious bovine rhinotrocheitis virus

Details Recombinant infectious bovine rhinotrocheitis virus Recombinant infectious bovine rhinotrocheitis virus

1995-02-01

1998-06-09

Guzo, David

Chemistry: molecular biology and microbiology

Vector, per se

4351723, C12N 1586, C12N 1546

Patent

active

057632693

ABSTRACT:
The present invention provides a hybrid, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the hybrid, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus and at least one foreign DNA sequence.
Also provided is an attenuated, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the attenuated, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus, from which at least a portion of a repeat sequence has been deleted.
Also provided are vaccines comprising the viruses of the invention and methods of immunizing animals against various disease.

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