Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1997-09-30
1998-12-22
Caputa, Anthony C.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241521, 4241581, 4241721, 5303871, 5303873, 53038823, A61K 39395, C07K 1600, C12P 2108
Patent
active
058515259
ABSTRACT:
Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
REFERENCES:
patent: 5096704 (1992-03-01), Coffman et al.
Collet, et al., "A Binary Plasmid System for Shuffling Combinatorial Antibody Libraties", Proceedings of the National Academy of Sciences, 89, No. 21, pp. 10026-10030. Nov., 1992.
Clark, et al., "Enzyme-Linked Immunosorbent Assay (ELISA): Theorectical and Practical Aspects", Enzyme-Immunoassay, CRC-Press, Inc., pp. 167-179 (1980).
Kabat, et al., "Sequences of Proteins of Immunological Interest", Fourth Ed., published by U.S. Dept. of Health and Human Services, pp. 60, 164 (1987).
Coffman, et al., "Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia n Mice", Science, vol. 245: pp. 308-310, (1989).
Ames, Jr. Robert S.
Appelbaum Edward Robert
Chaiken Irwin M.
Cook Richard M.
Gross Mitchell Stuart
Caputa Anthony C.
Eagle Alissa M.
King William T.
Lentz Edward T.
Navarro Mark
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