Recombinant IL-5 antagonists useful in treatment of IL-5 mediate

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

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4241521, 4241581, 4241721, 5303871, 5303873, 53038823, A61K 39395, C07K 1600, C12P 2108

Patent

active

058515259

ABSTRACT:
Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.

REFERENCES:
patent: 5096704 (1992-03-01), Coffman et al.
Collet, et al., "A Binary Plasmid System for Shuffling Combinatorial Antibody Libraties", Proceedings of the National Academy of Sciences, 89, No. 21, pp. 10026-10030. Nov., 1992.
Clark, et al., "Enzyme-Linked Immunosorbent Assay (ELISA): Theorectical and Practical Aspects", Enzyme-Immunoassay, CRC-Press, Inc., pp. 167-179 (1980).
Kabat, et al., "Sequences of Proteins of Immunological Interest", Fourth Ed., published by U.S. Dept. of Health and Human Services, pp. 60, 164 (1987).
Coffman, et al., "Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia n Mice", Science, vol. 245: pp. 308-310, (1989).

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