Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1996-05-20
1998-09-22
Eisenschenk, Frank C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530324, 5303888, 5303871, 5303893, 5303913, C07K 1646, C07K 1400
Patent
active
058115226
ABSTRACT:
The invention provides for the production of several humanized murine antibodies specific for the antigen FB5, which is recognized by the murine antibody FB5. The FB5 antigen is expressed on the luminal surface of vascular endothelial cells of a wide range of malignant tumours. The invention also provides for numerous polynucleotide encoding humanized FB5 specific antibodies, expression vectors for producing humanized FB5 specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized FB5 specific antibodies. Additionally, the invention provides methods of treating cancer using FB5 specific antibodies.
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patent: 4816567 (1989-03-01), Cabilly et al.
patent: 5225539 (1993-07-01), Winter
Rettig et al., "Identification of Endosialin, a Cell Surface Glycoprotein of Vascular Endothelial Cells in Human Cancer", Proc. Natl. Acad. Sci. USA 89:10832-10836 (1992).
Reichman et al., "Reshaping Human Antibodies for Therapy", Nature 332:323-327 (1988).
Carr Francis
Garin-Chesa Pilar
Old Lloyd J.
Rettig Wolfgang J.
Wallace Thomas Paul
Eisenschenk Frank C.
Ludwig Institute for Cancer Research
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