Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1989-05-03
1992-08-25
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530395, 530820, 530402, C07K 1300
Patent
active
051420260
ABSTRACT:
Disclosed is a novel recombinant human lyphotoxin (LT) mutein which combines with an antibody at an inactive site of an LT molecule and liberates the LT molecule easily from the antibody after incorporation of the mutein into tumor cells.
The recombinant human LT mutein is prepared by introducing a polydeoxyribonucleic acid containing a nucleotide sequence coding for the particular amino acid sequence into a replicable vector, transforming a microorganism or a cell with the recombinant DNA thus obtained, and cultivating the resulting transformant to express genetic information of the polydeoxyribonucleic acid.
The recombinant human LT mutein is useful for tumor-selective carcinostatics, and effective for increasing the actively of LT and reducing the side effects thereof.
REFERENCES:
patent: 4677063 (1987-06-01), Mark et al.
patent: 4677064 (1987-06-01), Mark et al.
patent: 4752525 (1988-06-01), Granger et al.
patent: 4920196 (1990-04-01), Aggarwal
Pennicor et al, Nature Mar. 2, 1984, pp. 724-729.
CA vol. 108, #92969x, Kakutani et al.
Bringman et al., Hybridoma, 6, 489 (1987).
Gray et al., Nature, 312, 721 (1984).
Tada et al., Journal of Immunoassay, 10, 93 (1989).
Tada et al., Hybrodoma, 8, 73 (1989).
Tada et al., The Physico-chemical Biology, 33, 39 (1989).
Iwasa Susumu
Tada Hiroko
Conlin David G.
Draper Garnette D.
Linek Ernest V.
Takeda Chemical Industries Ltd.
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