Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1994-06-15
1999-08-10
Martinell, James
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
514 2, 514 12, 435 6952, A61K 3820
Patent
active
059360666
ABSTRACT:
The invention relates to the cloning of the human IL-1 gene, its engineering into suitable expression vectors, transformation of host organisms with such expression vectors and production of biologically active recombinant human IL-1 by culture of such transformed cells. Additionally, the invention relates to the isolation and use of the resulting recombinant human IL-1 polypeptides.
REFERENCES:
patent: 4342832 (1982-08-01), Goeddel et al.
patent: 4406830 (1983-09-01), Fabricius et al.
patent: 4411992 (1983-10-01), Gillis
patent: 4503035 (1985-03-01), Pestka et al.
patent: 4508833 (1985-04-01), Sonneborn et al.
patent: 4518584 (1985-05-01), Mark et al.
patent: 4711842 (1987-12-01), Taniyama et al.
patent: 4762914 (1988-08-01), Auron et al.
Oppenheim et al., 1986, There is more than one interleukin 1, Immunology Today 7(2):45-57.
Dukovich et al., 1986, Stimulation of fibroblast proliferation and prostaglandin production by purified recombinant murine interleukin 1, Clin Immunol and Immunopathol 38:381-389.
Lomedico et al., 1986, Molecular biology of interleukin-1, Cold Spring Harbor Symposia on Quantitative Biology, vol. Ll, pp. 631-639.
Tsunasawa et al, 1985, Amino terminal processing of mutant forms of yeast ISO-1-cytochrome c, J Biol Chem 260(9):5382-5391.
Kronheim et al., 1985, Human interleukin 1: purification to homogeneity, J Exp Med 161:490-502.
Wood et al., 1985, The four biochemically distinct species of human interleukin 1 all exhibit similar biologic activities, J Immunol 134(2):895-903.
Auron et al., 1985, Human and Murine Interleukin 1 Possess Sequence and Structural Similarities, J. Mol. Cell. Immunol. 2:169-177.
Krakauer, 1985, Purification to homogeneity of biologically active human interleukin 1, Chemical Abstracts v102, p457 abstract 219322q.
Prestidge, 1985, Partial characterization of the high and low molecular weight forms of P388D1-derived interleukin 1, Chemical Abstracts v102, p446, abstract 77013p.
Saklatvala et al., 1985, Pig Interleukin 1, J. Exp. Med. 162:1208-1222.
March et al., 1985, Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs, Nature 315(6021):641-647.
Cameron et al., 1985, Amino acid sequence analysis of human interleukin 1 (IL-1): evidence for biochemically distinct forms of IL-1, J Exp Med 162:790-801.
Sherman et al., 1985, Methionine or not methionine at the beginning of a protein, Bioessays 3(1):27-31.
Furutani et al., 1985, Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor, Nucleic Acids Research 13(16):5869-5882.
Matsushima et al., 1985, Purification of human interleukin 1 from human monocyte culture supernatants and identity of thymocyte comitogenic factor, fibroblast-proliferation factor, acute-phase protein-inducing factor, and endogenous pyrogen, Cellular Immunology 92:290-301.
1985, Points to Consider in the Production and Testing of New Drugs and Biologicals Produced by Recombinant DNA Technology, Office of Biologics Research and Review Center for Drugs and Biologics.
1985, Million Dollar Directory, Series 1985, Dun's Marketing Services, ISSN 0734-2861.
1985, Interleukin-1 Genes Are Cloned, Science 228:1076-1077.
Kurt-Jones et al., 1985, Identification of a membrane-associated interleukin 1 in macrophages, Proc Nat Acad Sci USA 82:1204-1208.
Giri et al., 1985, Studies on the synthesis and secretion of interleukin 1, Journal of Immunology, vol. 134(1):343-349.
Mosley et al., 1985, The cloning and expression of two distinct human interleukin-1 (IL-1) cDNAs, Progress in Leukocyte Biology 2:521-532. Progress in Leukocyte Biology, Sherwood M. Reichard, ed., Alan R. Liss, Inc., New York, pp.521-532.
Sahasrabuddhe et al., 1985, Intracellular Human Il-1: A precursor for the secreted monokine, Lymphokine Research 4(3):205-213.
Durum et al., 1985, Interleukin 1: An immunological perspective, Ann. Rev. Immunology 3:263-287.
Dinarello, C.A., 1985, An update on human interleukin-1: From molecular biology to clinical relevance, Journal of Clinical Immunology 5(5):287-297.
Krakauer, 1984-85, Purification to homogeneity of biologically active human interleukin 1, Preparative Biochem 14(5): 449-470.
Auron et al., 1984, Nucleotide sequence of human monocyte interleukin 1 precursor cDNA, Proc. Natl. Acad. Sci. U.S.A. 81:7907-7911.
Auron et al., 1984, Molecular cloning of human interleukin-1, Lymphokine Research 3:285.
Schmidt, J.A., 1984, Purification and partial biochemical characterization of normal human interleukin 1, J. Exp. Med. 160:772-787.
Dinarello, 1984, Interleukin-1, Review of Infectious Diseases 6(1):51-95.
Devereux et al., 1984, A comprehensive set of sequence analysis programs for the VAX, Nucleic Acids Res 12(1):387-395.
Morinaga et al., 1984, Improvement of Oligonucleotide-Directed Site-Specific Mutagenesis Using Double-Stranded Plasmid DNA, Bio/technology pp. 636-639.
Matsushima et al., 1984, purification of human interleukin 1 and identity of thymocyte co-mitogenic factor, fibroblast proliferation factor and acute phase protein inducing factor, Fourth International Lympho. Workshop--Molecular and Cellular Biology of Lympho. Abstract p. 259.
Windle et al., 1984, Induction of interleukin 1 messenger RNA and translation in oocytes, J Immunology 132(3):1317-1322.
Dinarello, 1984, Interleukin-1 and the Pathogenesis of the Acute-Phase Response, New England J. of Med. 311:1413-1419.
Dayer et al., 1984, Induction of human interleukin 1 MRNA measured by collagenase-and prostaglandin E2-stimulating activity in rheumatoid synovial cells, Eur. J. Immunol. 14:898-901.
1984, Therapeutic control of inflammatory disease, Program of events-2nd International Conf. Inflammation Research Association.
Lomedico et al., 1984, Cloning and expression of murine interleukin-1 cDNA in Escherichia coli, Nature 312(5993):458-462.
1984, Human IL-1 gene cloning spawns counter-claims, Biotechnology Newswatch Monday Nov. 19, 1984 p. 2 (McGraw Hill).
Kock and Luger, 1984, Purification of human interleukin 1 by high-performance liquid chromatography, J Chromatography 296:293-300.
Scala et al., 1984, Human Large Granular Lymphocytes Are Potent Produces of Interleukin-1, Nature 309:56-59.
Dinarello et al., 1984, Cleavage of human interleukin 1: isolation of a peptide fragment from plasma of febrile humans and activated monocytes, J Immunology 133(3):1332-1338.
Alberts et al., 1983, The Immune System, Molecular biology of the cell, p. 1006.
Lachman, 1983, Human interleukin 1: purification and properties, FASEB J 42(9):2639-2645 (Fed. Proc.).
Yip, 1983, Stimulation of lymphokine production by teleocidin, aplysiatoxin and debromoaplysiatoxin, Chem Abstracts 99(9):466 No. 68697g.
Gross and Meienhofer, eds., 1983, Synthesis of polypeptides by recombinant DNA methods, The Peptides, pp.39-41.
Gubler and Hoffman, 1983, Simple and very efficient method for generating cDNA libraries, Gene 25(2-3):263-269.
Mizel et al., 1983, Preparation of Goat Antibodies Against Interleukin 1: Use of an Immunoadsorbent to Purify Interleukin 1, J Immunol 131:1834-1837.
Beltz et al., 1983, Isolation of Multigene Families and Determination of Homologies by Filter Hybridization Methods, Methods Enzymol 100:266-285.
Krakauer and Oppenheim, 1983, Interleukin 1 production by a human acute monocytic leukemia cell line, Cellular Immunology 80:223-229.
Hanahan, 1983, Studies on transformation of Escherichia coli with plasmids, J Mol Biol 166:557-580.
Yip, 1983, Stimulation of lymphokine production by teleocidin, aplysiatoxin and debromoaplysiatoxin, Cell Immunol 79(2):389-395.
Alberts et al., 1983, Recombinant DNA Technology, Molecular Biology of The Cell, Garland Publishing, NY, pp. 185-196.
Di Sabato, 1982, Purification and initial characterization of rat interleukin 2, Proc Nat Acad Sci USA 79(9):3020-3023.
Schmidt et al., 1982, Interleukin 1, a potential regulator of fibroblast proliferation, J Immunol 128:2177-2182.
Acuto et al., 1982, An efficient method for purification of human T-cell growth factor, J Immunol Met 53:15-26.
Welte et al., 1982, Purification of human interleukin 2 to apparent homogeneity and its molecula
Gubler Ulrich A.
Lomedico Peter T.
Mizel Steven B.
Hoffman La-Roche Inc.
Martinell James
The Pennsylvania State University
LandOfFree
Recombinant human interleukin-1.alpha. does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant human interleukin-1.alpha., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant human interleukin-1.alpha. will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1121194