Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-01-07
2000-05-16
Eyler, Yvonne
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303901, 5303871, 4241301, 4241331, 435328, C12P 2108, C07K 1600, A61K 39395, C12N 506
Patent
active
060639059
ABSTRACT:
Disclosed are compositions and methods of use that comprise engineered IgA antibodies that, when administered to a host are secreted across the epithelium into the mucosal barriers of the body providing external passive immunotherapy against agents such as viral, bacterial and eukaryotic pathogens. Also disclosed are mini antibodies comprising the minimal transcytosis domains.
REFERENCES:
patent: 5698679 (1997-12-01), Nemazee
Carayannopoulos et al 1994 Proc. Natl. Acad. Sci. 91:8348-8352.
Quirakkoo et al 1996 Immunotechnology 2(3):219-228 Abstract Only.
Castilla et al., Interference of coronavirus infection by expression of immunoglobulin G (IgG) of IgA virus-neutralizing antibodies, J Virol., 71(7):5251-5258, 1997.
International Search Report dated Apr. 27, 1998 (PCT/US98/00614) (UTFD:505P).
Capra J. Donald
Carayannopoulos Leon N.
Hexham Jonathan M.
Max Edward E.
Board of Regents , The University of Texas System
Eyler Yvonne
The United States of America as represented by the Department of
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