Recombinant human cytomegalovirus having a US2 deletion

Details Recombinant human cytomegalovirus having a US2 deletion Recombinant human cytomegalovirus having a US2 deletion

1995-07-31

1998-12-01

McKelvey, Terry A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4351721, 4351723, 4352351, 435236, 4353201, A61K 39245, C12N 701, C12N 704, C12N 1563

Patent

active

058434585

ABSTRACT:
Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down-regulation of cell surface expression of MHC class I. A recombinant mutant HCMV which fails to down-regulate class I heavy chain expression is described. A method of controlling down-regulation of MHC class I expression in a cytomegalovirus infected cell, a pharmaceutical composition, a vaccine composition, a method of preventing or reducing susceptibility to acute cytomegalovirus in an individual, and a virus based gene therapy vector are also described.

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