Recombinant human cytomegalovirus containing foreign gene

Details Recombinant human cytomegalovirus containing foreign gene Recombinant human cytomegalovirus containing foreign gene

1990-10-16

1993-12-28

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

4351723, 4353201, 435 691, C12N 701, C12N 1586, C12N 938, C12P 2100

Patent

active

052738760

ABSTRACT:
The present invention provides a virus comprising a DNA sequence essential for replication of a human cytomegalovirus and at least one foreign DNA sequence adapted for expression in a host. The foreign DNA sequence may encode a human immunodeficiency virus anti-sense mRNA sequence or an antigenic polypeptide, e.g., a malarial surface antigen.
Also provided are therapeutic compositions and vaccines which comprise the novel viruses of the present invention.

REFERENCES:
patent: 4707357 (1987-11-01), Dame et al.
Mocarski et al. 1985 PNAS 82:1266-1270.
Foecking et al. 1986 Gene 45:101-105.
Thomsen, D. R., et al., Proc. Natl. Acad. Sci. USA, vol. 81, pp. 659-663 (1984).
Zamecnik, P. C., et al., Proc. Natl. Acad. Sci. USA, vol. 83, pp. 4143-4146 (1986).
Rice, G. P. A., et al., Proc. Natl. Acad. Sci. USA, vol. 81, pp. 6134-6138 (1984).
Schrier, R. D., et al., Science, vol. 230, pp. 1048-1051 (1985).
Braun, R. W. and Reiser, H. C., Journal of Virology, vol. 60, pp. 29-36 (1986).
Lee, G. T.-Y., et al., Proc. Natl. Acad. Sci. USA, vol. 79, pp. 6612-6616 (1982).
Shih, M.-F., et al., Proc. Natl. Acad. Sci. USA, vol. 81, pp. 5867-5870 (1984).
Lowe, R. S., et al., Proc. Natl. Acad. Sci. USA, vol. 84, pp. 3896-3900 (1987).
Post, L. E. and Roizman, B., Cell, vol. 25, pp. 227-232 (1981).
Poffenberger, K. L., et al., Proc. Natl. Acad. Sci. USA, vol. 80, pp. 2690-2694 (1981).
Gibson, M. G. and Spear, P. G., Journal of Virology, vol. 48, pp. 396-404 (1983).
Knipe, D. M., et al., Proc. Natl. Acad. Sci. USA, vol. 75, pp. 3896-3900 (1978).
Mocarski, E. S., et al., Cell, vol. 22, pp. 243-255 (1980).
Post, L. E., et al., Cell, vol. 24, pp. 555-565 (1981).
Gehrz, R. C., et al., Archives of Internal Medicine, vol. 140, pp. 936-939 (1980).
Glazer, J. P., et al., Annals of Internal Medicine, vol. 91, pp. 676-683 (1979).
Quinnan, G. V. Jr., et al., Annals of Internal Medicine, vol. 101, pp. 478-483 (1984).
Elek, S. D. and Stern, H., Lancet, vol. 1, pp. 1-5 (1974).
Neff, B. J., et al., Proceedings of the Society for Experimental Biology and Medicine, vol. 160, pp. 32-37 (1979).
Plotkin, S. A., et al., Journal of Infectious Diseases, vol. 134, pp. 470-475 (1976).

Affiliated with

Also associated with

Rating

Recombinant human cytomegalovirus containing foreign gene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Recombinant human cytomegalovirus containing foreign gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant human cytomegalovirus containing foreign gene will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1542091