Recombinant human cytomegalovirus containing foreign gene

Details Recombinant human cytomegalovirus containing foreign gene Recombinant human cytomegalovirus containing foreign gene

1993-12-09

1996-10-01

Vogel, Nancy T.

Chemistry: molecular biology and microbiology

Vector, per se

4351723, 4352351, 536 231, 536 237, 536 241, C12N 1586, C12N 701, C12N 1500, C12N 1511

Patent

active

055610633

ABSTRACT:
The present invention provides a virus comprising a DNA sequence essential for replication of a human cytomegalovirus and at least one foreign DNA sequence adapted for expression in a host. The foreign DNA sequence may encode a human immunodeficiency virus anti-sense mRNA sequence or an antigenic polypeptide, e.g., a malarial surface antigen.
Also provided are therapeutic compositions and vaccines which comprise the novel viruses of the present invention.

REFERENCES:
patent: 4707357 (1987-11-01), Dame
Foecking et al, Gene 45:101-105 (1986).
Mocarski et al., Proc. Natl. Acad. Sci., 82:1266-1270 (1985).

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