Recombinant human cell for bone and cartilage cell formation

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S352000, C435S363000, C435S366000, C435S372000, C435S455000

Reexamination Certificate

active

06908764

ABSTRACT:
The invention relates to a recombinant human cell of undifferentiated mesenchyma for bone and cartilage cell formation, the human cell having the ability to express Tbr-1, Brachyury or another member of the T-box family.

REFERENCES:
Allay, J.A. et al., LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors.Human gene thereapy8:1417-1427, 1997.
Bulfone et al., T-Brain-1: A Homolog of Brachyury Whose Expression Defines Molecularly Distinct Domains Within the Cerebral Cortex,Neuron, 15:63-78, Jul. 1995.
Chapman et al., Expression of the T-Box Family Genes, Tbx1-Tbx5, During Early Mouse Development,Developmental Dynamics, pp. 379-390, Feb. 7, 1996.
Chapman et al., Three Neural Tubes in Mouse Embryos with Mutations in the T-Box gene Tbx6,Nature391:695-697, Feb. 12, 1998.
de Angelis et al., Promotion of Gastrulation by Maternal Growth Factor in Cultured Rabbit Blastocysts,Cell&Tissue Research, pp. 147-154, May 17, 1995.
Deonarain; Ligand-targeted receptor-mediated vectors for gene delivery,Exp. Opin. Ther. Patenrts8(1):53-69, 1998.
Herrmann et al., Cloning of the T Gene Required in Mesoderm Formation in the Mouse,Nature343:617-622, Feb. 15, 1990.
Jim Smith, Brachyury and the T-Box Genes,Current Opinion in Genetics and Development, pp. 474-480, 1997.
Kispert et al., Homologs of the Mouse Brachyury Gene are Involved in the Specification of Posterior Terminal Structures in Drosophila, Tribolium, and Locusta,Genes&Development, pp. 2137-2150, Jul. 25, 1994.
Kispert et al., The T Protein Encoced by Brachyury is a Tissue-Specific Transcription Factor,The EMBO Journal14:4763-4772, Nov. 19, 1995.
Li et al., Holt-Oram Syndrome is Caused by Mutations in TBX5, a Member of the Brachyury (T) Gene Family,Nature Genetics15:21-29, Jan. 1997.
Li, K.J. et al., Retroviral-mediated gene transfer into human bone marrow stromal cells: Studies of efficiency and in vivo survival in SCID mice.Eur. J. Haematol.55:302-306, 1995.
Miller et al., Targeted vectors for gene therapy,FASEB J.9:190-199, 1995.
Müller et al., Crystallographic Sttructure of the T Domain-DNA Complex of the Brachyury Transcription Factor,Nature389:884-888, Oct. 23, 1997.
Papaioannou et al., The T-Box Gene Family,BioEssays20:9-19, 1998.
Simon et al., A Novel Family of T-Box Genes in Urodele Amphibian Limb Development and Regeneration: Candidate Genes Involved in Vertebrate Forelimb/Hindlimb Patterning,Development124:1355-1366, 1997.
Spranger et al., Muscular Involvement in the Holt-Oram Syndrome,Med Genet, pp. 978-981, 1997.
Verma; Gene therapy-promises, problems and prospects;Nature vol.389:239-242, 1997.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Recombinant human cell for bone and cartilage cell formation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Recombinant human cell for bone and cartilage cell formation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant human cell for bone and cartilage cell formation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3475937

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.