Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1997-10-14
2000-07-18
Fitzgerald, David L.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
536 235, 435 6, 435325, 4352542, 435354, 435356, 435358, 435364, 435365, C12N 1512, C07K 14435
Patent
active
060906235
ABSTRACT:
Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. In particular DNA clones encoding each of the .alpha..sub.1A-1, .alpha..sub.1A-2, .alpha..sub.1E-1, .alpha..sub.1C-2, .alpha..sub.1E-3, .beta..sub.3-1, .beta..sub.2C, .beta..sub.2D, .beta..sub.2E and .beta..sub.4 subunits of human calcium channels are provided. Cells and vectors containing the DNA, subunit specific antibodies and nucleic acid probes and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
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Ellis Steven B.
Harpold Michael M.
McCue Ann F.
Williams Mark E.
Coppola Joseph A.
Fitzgerald David L.
Merck & Co. , Inc.
Tribble Jack L.
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