Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1997-05-20
1999-02-23
Feisee, Lila
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
4241411, 4241521, 4241551, 4241561, 4241721, 4241741, 4241781, 4241811, A61K 5100, A61K 39395
Patent
active
058740600
ABSTRACT:
The invention provides for the production of several humanized murine antibodies specific for the antigen Lewis Y, which is recognized by the murine antibody Lewis Y. The Lewis Y antigen is expressed in normal tissues but the level of expression is higher in certain tumor types so that the antigen can be used as a marker for cells of some breast, colon, gastric, esophageal, pancreatic, duodenal, lung, bladder and renal carcinomas and gastric and islet cell neuroendocrine tumors. The invention also provides for numerous polynucleotide encoding humanized Lewis Y specific antibodies, expression vectors for producing humanized Lewis Y specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis Y specific antibodies. Additionally, the invention provides methods of treating cancer using humanized Lewis Y specific antibodies.
REFERENCES:
patent: 5242824 (1993-09-01), Hellstrom et al.
patent: 5491088 (1996-02-01), Hellstrom et al.
Queen et al (Pnas, 86:10029-10033), 1989.
Reichmann et al (Nature, 332:323-327), 1988.
Armour Kathryn Lesley
Carr Francis Joseph
Garin-Chesa Pilar
Kitamura Kunio
Old Lloyd J.
Feisee Lila
Memorial Sloan Kettering Cancer Center
Ungar Susan
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