Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-02-14
1998-08-18
Feisee, Lila
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530380, 530386, 5303873, 5303877, 5303881, 5303882, 5303888, 53038885, C07K 1400, A61K 3816, C12P 2108
Patent
active
057959617
ABSTRACT:
The invention provides for the production of several humanized murine antibodies specific for the Lewis b antigen, which is recognized by the murine antibody 58-1066. The antigen is expressed on cell lines from colon, lung, bladder, breast, renal, pancreatic and ovarian cancers. The expression of the antigen is greatly increased in cancer tissues as compared to its expression in the corresponding normal tissue. The invention also provides for numerous polynucleotide encoding humanized Lewis b antigen specific antibodies, expression vectors for producing humanized Lewis b antigen specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis b antigen specific antibodies. Additionally, the invention provides methods of treating cancer using Lewis b antigen specific antibodies.
REFERENCES:
patent: 4607009 (1986-08-01), Steplewski et al.
Suhl (S. Histochem. Cytochem 33:309-314), 1985.
Carr Frank J.
Harris William J.
Kitamura Kunio
Old Lloyd J.
Wallace T. Paul
Feisee Lila
Ludwig Institute for Cancer Research
Ungar Susan
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