Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2008-09-09
2008-09-09
Benzion, Gary (Department: 1637)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C435S006120
Reexamination Certificate
active
10838476
ABSTRACT:
Disclosed are methods of inhibiting autoreactive immune cell proliferation in a mammal, involving administering to the mammal a therapeutically effective amount of recombinant human alpha-fetoprotein or an immune cell anti-proliferative fragment or analog thereof.
REFERENCES:
patent: 4692332 (1987-09-01), McMichael
patent: 4877610 (1989-10-01), McMichael
patent: 4966753 (1990-10-01), McMichael
patent: 4970071 (1990-11-01), McMichael
patent: 4996193 (1991-02-01), Hewitt et al.
patent: 5130415 (1992-07-01), Tecce et al.
patent: 5206153 (1993-04-01), Tamaoki et al.
patent: 5302698 (1994-04-01), Morinaga et al.
patent: 5365948 (1994-11-01), McMichael
patent: 5384250 (1995-01-01), Murgita
patent: 5723585 (1998-03-01), Baker et al.
patent: 5965528 (1999-10-01), Murgita
patent: 6288034 (2001-09-01), Murgita
patent: 6331611 (2001-12-01), Murgita
patent: 6774108 (2004-08-01), Murgita
patent: 0 487 229 (1997-09-01), None
patent: 2005866 (1990-01-01), None
patent: WO 86/04241 (1986-07-01), None
patent: WO 94/10199 (1994-05-01), None
patent: WO 96/22787 (1996-08-01), None
patent: WO 01/15709 (2001-03-01), None
Irony-Tur-Sinai et al. Experimental Neurology, vol. 198, pp. 136-144, 2004.
Parker et al. Protein Expression and Purification, vol. 38, pp. 177-183, 2004.
Abramsky et al., “Alpha-Fetoprotein Suppresses Experimental Allergic Encephalomyelitis,”Journal of Neuroimmunology2:1-7 (1982).
Abramsky et al., “A Role of Alpha-Fetoprotein in Autoimmune Diseases,”Annals New York Academy of Sciences417:108-116 (1983).
Aoyagi et al., “Differential Reactivity of Alpha-Fetoprotein with Lectins and Evaluation of its Usefulness in the Diagnosis of Hepatocellular Carcinoma,”Gann75:809-815 (1984).
Biddle et al., “ Specific Cytoplasmic Alpha-Fetoprotein Binding Protein in MCF-7 Human Breast Cancer Cells and Primary Breast Cancer Tissue,”Breast Cancer Research and Treatment10:279-286 (1987).
Boismenu et al., “Expression of Domains of Mouse Alpha-Fetoprotein inEscherichia Coli,” Life Sciences43:673-681 (1988).
Brenner et al., “Inhibitory Effect of Alpha-Fetoprotein on the Binding of Myasthenia Gravis Antibody to Acetylcholine Receptor,”Proc. Natl. Acad. Sci. USA77: 3635-3639 (1980).
Brenner et al., “Immunosuppression of Experimental Autoimmune Myasthenia Gravis by Alpha-Fetoprotein Rich Formation,”Immunology Letters3:163-167 (1981).
Brenner et al., “Influence of Alpha-Fetoprotein on the in Vitro and in Vivo Immune Response to Acetylcholine Receptor,”Annals New York Academy of Sciences377:208-221 (1981).
Buamah et al., “Serum Alpha-Fetoprotein Heterogeneity as a Means of Differentiating Between Primary Hepatocellular Carcinoma and Hepatic Secondaries,”Clinica. Chimica. Acta.139:313-316 (1984).
Buschman et al., “Experimental Myasthenia Gravis Induced in Mice by Passive Transfer of Human Myasthenic Immunoglobulin,”Journal of Neuroimmunology13:315-330 (1987).
Caturla et al., “The Thyroid Hormone Down-Regulates the MouseAlpha-Foetoprotein Promoter,”Molec. and Cell. Endocrin.135:139-145 (1997).
Cohen et al., “Suppression by Alpha-Fetoprotein of Murine Natural Killer Cell Activity Stimulated in Vitro and in Vivo by Interferon and Interleukin 2,”Scand. J. Immunol.23:211-223 (1986).
Dattwyler et al., “Binding of Alpha-Foetoprotein to Murine T Cells,”Nature256:656-657 (1975).
Flalova et al., “Serum Levels of Trophoblast-Specific Beta-1-Globulin (SP1) and Alpha-1-Fetoprotein (AFP) in Pregnant Women With Rheumatoid Arthritis,”Ceskoslovenska Gynekologie56:166-170 (1991) (Abstract only).
Galarneau et al., “The Alpha1-Fetoprotein Locus is Activated by a Nuclear Receptor of theDrosophiliaFTZ-F1 Family,”Molec. and Cell. Biol.16:3853-3865 (1996).
Gershwin et al., “The Influence of Alpha-Fetoprotein on Moloney Sarcoma Virus Oncogenesis: Evidence for Generation of Antigen Nonspecific Suppressor T Cells,”The Journal of Immunology121:2292-2297 (1978).
Giuliani et al., “Synthesis and Characterization of a Recombinant Fragment of Human Alpha-Fetoprotein with Antigenic Selectivity Versus Albumin,”Protein Engineering2:605-610 (1989).
Glazier et al., “Graft-Versus-Host Disease in Cyclosporin A-Treated Rats After Syngeneic and Autologous Bone Marrow Reconstitution,”J. Exp. Med.158:1-8 (1983).
Goidl et al., “Studies on the Mechanisms of Alpha-Fetoprotein Induction of Immune Suppressive Activity,”from Developmental Immunobiology, Proceedings of the Fifth Irwin Strasburger Memorial Seminar on Immunology eds.Siskind et al., 35-55 (1979).
Hamel et al., “Phenotype and Function of Bone Marrow-Derived T- and Non-T-Cells Activated in Vitro by Alpha-Fetoprotein,”Biological Activities of Alpha1-Fetoprotein1:167-177 (1987).
Heyward et al., “Early Detection of Primary Hepatocellular Carcinoma by Screening for Alpha-Fetoprotein in High-Risk Famillies,”The Lancet2:1161-1162 (1983).
Hooper et al., “Regulation of Murine T-Cell Responses to Autologous Antigens by Alpha-Fetoprotein,”Celluar Immunology63:417-425 (1981).
Hooper et al., “Suppression of Primary and Secondary Autologous Mixed Lymphocyte Reactions by Murine Alphafetoprotein,”Oncodevelopmental Biology and Medicine3:151-160 (1982).
Hooper et al., “Selective Inhibition of Murine T-Cell Proliferation and Lymphokine-Activated Natural Killer Cell Function by Alpha-Fetoprotein,”Biological Activities of Alpha1-Fetoprotein eds.Mizejewski et al. 1:153-165 (1987).
Hooper et al., “Human AFP Inhibits Cell Proliferation and NK-Like Cytotoxic Activity Generated in Autologous, but not in Allogeneic Mixed Lymphocyte Reactions,”Biological Activities of Alpha1-Fetoprotein2:183-197 (1989).
Hoskin et al., “In Vitro Activation of Bone Marrow-Derived T-and Non-T-Cell Subsets by Alpha-Fetoprotein,”Cellular Immunology96:163-174 (1985).
Hoskin et al., “Analysis of Pregnancy-Associated Immunoregulatory Pathways,”Alpha-Fetoprotein and Congenital Disorders59-78 (1985).
Hoskin et al., “Specific Maternal Anti-Fetal Lymphoproliferative Responses and Their Regulation by Natural Immunosuppressive Factors,”Clin. Exp. Immunol.76:262-267 (1989).
Innis et al., “Amplification of Alpha-Fetoprotein Complementary DNA by Insertion into a Bacterial Plasmid,”Archives of Biochemistry and Biophysics195:128-135 (1979).
Ishiguro et al., “Serum Alpha-Fetoprotein Subfractions in Patients with Primary Hepatoma or Hepatic Metastasis of Gastric Cancer,”Cancer55:156-159 (1985).
Jacobson et al., “Inhibition of Estrogen-Dependent Breast Cancer Growth by a Reaction Product of Alpha-Fetoprotein and Estradiol, ”Cancer Research50:415-420 (1990).
Jiang et al., “Role of CD8+ T Cells in Murine Experimental Allergic Encephalomyelitis,”Science256:1213-1215 (1992).
Karasuyama et al., “Establishment of Mouse Cell Lines which Constitutively Secrete Large Quantities of Interleukin 2, 3, 4 or 5, Using Modified cDNA Expression Vectors,”Eur. J. Immunol.18:97-104 (1998),
Keller et al., “Immunosuppressive Properties of AFP: Role of Estrogens,” form Onco-Developmental Gene Expression eds. Fishman et al. 287-295 (1976).
Kikutani et al., “The Murine Autoimmune Diabetes Model: NOD and Related Strains,”Advances in Immunology51:285-322 (1992).
Line et al., “Medical Potential of AFP as a Tumor Imaging Agent,”Biological Activities of Alpha1-Fetoprotein2:139-148 (1989).
Lu et al., “Alpha-Fetoprotein Inhibits Macrophage Expression of Ia Antigens,”The Journal of Immunology132:1722-1727 (1984).
Masuda et al., “Selective Antitumor Effect of Thioether-Linked Immunotoxins Composed of Gelonin and Monoclonal Antibody to Alpha-Fetoprotein or its F(ab')2Fragment,”Tumor Biol.15:175-183 (1994).
Mizejewski, “Alpha-Fetoprotein Testing: Regulatory and Technic
Benzion Gary
Clark & Elbing LLP
Merrimack Pharmaceuticals, Inc.
Wilder Cynthia
LandOfFree
Recombinant human alpha-fetoprotein as an immunosuppressive... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant human alpha-fetoprotein as an immunosuppressive..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant human alpha-fetoprotein as an immunosuppressive... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3923437