Recombinant HT.sub.m4 gene, protein and assays

Details Recombinant HT.sub.m4 gene, protein and assays Recombinant HT.sub.m4 gene, protein and assays

1994-10-06

1996-09-03

Wax, Robert A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352523, 4353201, 536 235, C12N 500, C12N 120, C12N 1500, C07H 2104

Patent

active

055523129

ABSTRACT:
The invention relates to a recombinant DNA molecule which encodes a HT.sub.m4 protein, a transformed host cell which has been stably transfected with a DNA molecule which encodes a HT.sub.m4 protein and a recombinant HT.sub.m4 protein. The invention also relates to a method for detecting the presence of a hereditary atopy.

REFERENCES:
Shirakawa, Taro et al., "Association between atopy and variants of the .beta. subunit of the high-affinity immunoglobulin E receptor," Nature Genetics 7:125-130 (1994).
Ravetch, Jeffrey V., "Atopy and Fc receptors: mutation is the message?", Nature Genetics 7:117-118 (1994).
Kobayashi, Hirofumi et al., "Variability of 11q23 Rearrangements in Hematopoietic Cell Line Identified With fluorescence In Situ Hybridization," Blood 81(11):3027-3033 (1993).
Ravetch, Jeffrey V. and Kinet, Jean-Pierre "Fc Receptors," Annu. Rev. Immunol. 9:457-492 (1991).
Cookson, W. O. C. M. et al., "Maternal inheritance of atopic IgE responsiveness on chromosome 11q," The Lancet 340:381-384 (1992).
Cookson, William O. C. M. et al., "Linkage between Immunoglobuline Responses Underlying Asthma and Rhinitis and Chromosome 11q," The Lancet: 1292-1295, Jun. 10, 1989.
Davies, Kevin "Allergy by mutation," Nature 369:506 (1994).
Marsh, David G. and Meyers, Deborah A. "A major gene for allergy--fact or fancy?", Nature Genetics 2:252-254 (1992).
Adra, et al. (1994) Proc. Natl. Acad. Sci. USA 91: 10178-10182.
Kinet, et al. (1988) Proc. Natl. Acad. Sci. USA 85: 6483-6487.
Kuster, et al. (1992) J. Biol. Chem. 267: 12782-12787.
Maekawa, et al. (1992) FEBS lett. 302: 161-165.
Ra, et al. (1989) J. Biol. Chem. 264: 15323-15327.

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