Recombinant hormonal compositions and method

Details Recombinant hormonal compositions and method Recombinant hormonal compositions and method

1978-08-31

1980-02-19

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

041894260

ABSTRACT:
Non-covalent complementation of peptide hormonal fragments produces a recombinant with the hormonal activity of the native hormone. The fragments employed can be natural, synthetic or mixed natural-synthetic origin and can contain less than the total amino acid sequence of the native hormone or fragments derived from related hormones. In a preferred embodiment the human growth hormone (HGH) fragments [Cys(Cam).sup.53 -HGH-(1-134)] and [Cys(Cam).sup.165,182,189 -HGH-(141-191)] undergo non-covalent complementation to yield a recombinant having full growth-promoting and prolactin potency of the native human growth hormone.

REFERENCES:
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patent: 3853832 (1974-12-01), Li
patent: 3907765 (1975-09-01), Wang
patent: 4056520 (1977-11-01), Sonenberg et al.
Arch. Biochem. and Biophysic., 146, 233-236 (1971).
J. Org. Chem., 40, No. 9, 1227-1234 (1975).
J. Med. Chem. 18, No. 2 (1975), 124-126.
Endocrinol. 93, (1973), 848-857, 858-865, 866-873.
The Endocrine Society, 1970, 112.
Endocrinology 94, 1974, 883-891.
Endocrinology 96, 625-636.
Nature 237, 1972, 433-439.
Li, et al., Chem. Abst. 85, 1976, p. 186915K.

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