Chemistry: molecular biology and microbiology – Vector – per se
Patent
1997-08-15
2000-09-19
Guzo, David
Chemistry: molecular biology and microbiology
Vector, per se
536 232, 536 2372, 536 241, C12N 15869
Patent
active
061210439
ABSTRACT:
The present invention provides a hybrid, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the hybrid, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus and at least one foreign DNA sequence. Also provided is an attenuated, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the attenuated, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus, from which at least a portion of a repeat sequence has been deleted. Also provided are vaccines comprising the viruses of the invention and methods of immunizing animals against various disease.
REFERENCES:
patent: 4514497 (1985-04-01), Kit et al.
Rabinovich et al., Science, vol. 265, pp. 1401-1404, Sep. 2, 1994.
Cohen, J., Science, vol. 265, pp. 1371-1373, Sep. 2, 1994.
Jaenicke, R., Prog. Biophys. Molec. Biol., vol. 49, pp. 117-237, 1987.
Monsour, S.L. et al. (1985) "An adenovirus vector system used to express polyoma virus tumor antigens," Proc. Natl Acad Sci USA 82: 1359-1363.
Thummel, C. et al. (1983) "Translational Control of SV40 T Antigen Expressed from the Adenovirus Late Promotor," Cell 33: 455-464.
Solnick, D. et al. (1981) "Construction of an Adenovirus-SV40 Recombinant Producing SV40 T Antigen from an Adenovirus Late Promotor," Cell 24: 135-143.
Thummel, C. Amd Tjian, R. (1981) "Expression of SV40 T Antigen under Control of Anenovirus Promotors," Cell 23: 825-836.
Mackett, M. et al. (1982) "Vaccinia virus: A selectable eukaryotic cloning and expression vector," Proc Natl Acad Sci USA 79: 7415-7419.
Panicali, D. and Paoletti, E. (1984) "Construction of poxvirus as cloning vectors: Insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus," Proc Natl Acad Sci 79: 4927-4931.
Paoletti, E. et al (1984) "Construction of live vaccines using genetically engineered poxviruses: Biological activity of vaccinia virus recombinants expressing the hepatitis B virus surface antigen anf the herpes simplex virus glycoprotein D," Proc Natl Acad Sci 81: 193-197.
Smith, G.L. et al (1983) "Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen," Nature 302: 490-495.
Panicali, D. et al (1983) "Construction of live vaccines by using genetically engineered poxviruses: Biological activity of recombinant vaccinia virus expressing influenza virus hemagglutinin," Proc Natl Acad Sci 80: 5364-5368.
Smith, G.L. et al (1983) "Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistence to influenza virus infection in hamsters," Proc Natl Acad Sci 80: 7155-7159.
Smith, G.L. et al. (1984) "Plasmodium knowlesi Sporozite Antigen: Expression by Infectious Recombinat Vaccinia Virus," Science 224: 397-399.
Mackett, M. et al. (1985) "Vaccinia Virus Recombinants: Expression of VSV Genes and Protective Immunization of Mice and Cattle," Science 227: 433-435.
Knipe, D.M. et al. (1978) "Molecular genetics of herpes simplex virus: Demonstration of regions of obligatory and nonobligatory identity within diplod regions of the genome by sequence replacement and insertion," Proc Natl Acad Sci 75: 3896-3900.
Mocarski, E.S. et al. (1990) "Molecular Engineering of the Herpes Simplex Virus Genome: Insertion of a second L-S Junction into the Genome Causes Additional Genome Inversion," Cell 22: 243-255.
Post, L.E. et al. (1981) "Regulation of .alpha. Genes of Herpes simplex Virus: Expression of Chimeric Genes Produced by Fusion of Thymidine Kinase with .alpha. Gene Promotors," Cell 24: 555-565.
Post, L.E. and Roizman, B. "A generalized technique for Deletion of Specific Genes in Large Genomes: .alpha. Gene 22 of Herpes Simplex Virus 1 is not essential for Growth," (1981) Cell 25: 227-232.
Poffenberger, K.L. et al (1981) "Characterization of a viable, noninverting herpes simplex virus 1 genome derived by insertion and deletion of sequences at the junction of components L and S," Proc Natl Acad Sci 80: 2690-2694.
Gibson, M.G. and Spear, P.G. (1983) "Insertion Mutants of Herpes Simplex Virus Have a Duplication of the Glycoprotein D Gene and Express Two Different Forms of Glycoprotein D," Journal of Virology 48: 396-404.
Lee, G.T.-Y, et al (1982) "Expression of herpes simplex virus glycoprotein C from a DNA virus fragment inserted into the thymidine kinase gene of this virus," Proc Natl Acad Sci USA 79: 6612-6616.
Shih, M.-F., et al (1984) "Expression of hepatitis V virus S gene by herpes simplex virus 1 vectors carrying .alpha. and .beta. regulated gene chimeras," Proc Natl Acad Sci 81: 5867-5870.
Rea, T.J. et al (1984) "Mapping and Sequence of the Gene for the Pseudorabies Virus Glycoprotein Which Accumulates in the Medium of Infected Cells," Journal of Virology 54: 21-29.
Ihara, S. et al (1982) "Comparison of the Physical and Genetic Maps pf Pseudorabies Virus Shows That the Genetic Map is Circular," Virology 122: 268-278.
Kit, S., et al (1985) "Attenuated properties of thymidine kinase-nagative deletion mutant of pseudorabies virus," American Journal of Veterinary Research 46: 1359-1367.
Berns, A. et al (1985) "Presence of Markers for Virulence in the Unique Short Region of Repeat Region or Both of Pseudorabies Hybrid Viruses," Journal of Virology 53: 89-93.
Lomniczi, B. Et al (1984) "Deletions in the Genomes of Pseudorabies Virus Vaccine Strains and Existence of Four Isomers of the Geneomes," Journal of Virology 49: 970 979.
Haj-Ahmad, Y. and Graham, F.L. (1986) "Development of a Helper-Independent Human Adenovirus Vector and Its Use in the Transfer of the Herpes Simplex Virus Thymidine Kinase Gene," Journal of Virology 57: 267-274.
Gillepsie, J.H. et al (1986) "Response of Dairy Calves to Vaccinia Viruses That Express Foreign Genes," Journal of Clinical Virology 23: 283-288.
Fukuchi, K. et al (1984) "Structure of Marek's Disease Virus DNA: Detailed Restriction Enzyme Map," Journal of Virology 51: 102-109.
Richardson, M.A. et al (1984) "Nucleotide Sequence of the Gene Encoding the Serotype-Specific Antigen of Human Wa Rotavirus: Comparison with the Homologous Genes from Simian SA11 and UK Bovine Rotaviruses," Journal of Virology 51: 860-862.
Holland, T. C. et al. (1984) "Herpes Simplex Virus Type 1 Glycoprotein C-Negative Mutants Exhibit Multiple Phenotypes, Including Secretion of Truncated Glycoproteins," Journal of Virology 52: 566-574.
Churchill, A.E. (1969) "The Attenuation with Loss of Oncogenicity of the Herpes-type Virus of Marek's Disease (Strain HPRS-16) on Passage in Cell Culture," Journal of General Virology 4: 557-564.
Wathen, M.W. and Wathen L.M.K. (1986) "Characterization and Mapping of a Nonessential Pseudorabies Virus Glycoprotein," Journal of Virology 58: 173-178.
Mettenleiter, T.C. et al (1985) "Pseudorabies Virus Avirulent Strains Fail to Express a Major Glycoprotein," Journal of Virology 56: 307-311.
Van Oirschot, J.T. et al (1986) "Differentiation of Serum Antibodies from Pigs Vaccinated or Infected with Aujesky's Disease Virus by a Competitive Enzyme Immunoassay," Journal of General Virology 67: 1179-1182.
Hu, S. et al (1984) "Cloning and Expression of the Surface Glycoprotein gp195 of Porcine Transmissible Gastroenteritis Virus" in Modern Approaches to Vaccines, Chanok, R.M. amd Lerner, R.A. Eds., Cold Spring Harbor Press, pp. 219-223 (1984).
Spriggs, M.K. and Collins, P.L. (1986) "Human Parainfluenza Virus Type 3: Messenger RNAs, Ploypeptide Coding Assignments, Intergenic Sequences, and Genetic Map," Journal of Virology 59: 646-656.
Blumberg, B.M. et al (1985) "Dequence Determination of the Sendai Virus Fusion Protein Gene," Journal of General Virology, vol. 66: 317-331.
Hudson, P.J. et al (1986) Nucleic Acids Research 14: 5001-5012.
Cochran Mark D.
MacConnell William P.
MacDonald Richard D.
Shih Meng-Fu
Guzo David
Syntro Corporation
White John P.
LandOfFree
Recombinant herpesvirus of turkeys comprising a foreign DNA inse does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant herpesvirus of turkeys comprising a foreign DNA inse, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant herpesvirus of turkeys comprising a foreign DNA inse will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1071641