Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...
Patent
1993-02-26
1999-07-27
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant virus encoding one or more heterologous proteins...
4242291, 4352351, A61K 39255, A61K 39295, C12N 701
Patent
active
059286482
ABSTRACT:
The present invention relates to a recombinant herpesvirus of turkeys comprises foreign DNA inserted into a site in the herpesvirus of turkeys genome which is not essential for replication of the herpesvirus of turkeys. The invention further relates to homology vectors which produce recombinant herpesvirus of turkeys by inserting foreign DNA into herpesvirus of turkeys genome. Genetically-engineered virus S-FPV-062 is described in the Materials and Methods section which follows. One advantage of recombinant HVT as live vaccines is that they may be engineered to express only a limited number of antigens that are needed to confer protective immunity to the corresponding pathogens. Consequently, host animals vaccinated with the recombinant HVT can be distinguished from those which have been infected with the wild type virus by the absence of antigens that are normally present in the wild type virus.
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Zuc
Mosher Mary E.
Syntro Corporation
White John P.
LandOfFree
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