Recombinant herpes simplex viruses, vaccines and methods

Details Recombinant herpes simplex viruses, vaccines and methods Recombinant herpes simplex viruses, vaccines and methods

1986-04-25

1989-08-22

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435 70, 435 91, 435235, 4351723, 4353171, 435320, 935 32, 935 34, 935 57, 935 65, 424 89, 424 858, 536 27, C12P 2100, C12N 1500, C12N 700, A61K 3900

Patent

active

048595870

ABSTRACT:
Recombinant herpes viruses useful as effective ingredients in vaccines against both virulent HSV-1 and HSV-2 are disclosed. Methods of preparing the recombinant viruses, vaccines incorporating the viruses, and methods of immunizing a human host by inoculation with the vaccines are also disclosed.
The genomes of the recombinant viruses each comprise a mutant of the HSV-1 genome from which a portion thereof responsible for neurovirulence yet nonessential for growth is deleted. A gene from the HSV-2 genome responsible for coding an immunity-inducing glycoprotein is inserted in the mutant genome between the end points of deletion therein.

REFERENCES:
patent: 4554159 (1985-11-01), Roizman et al.
patent: 4569840 (1986-02-01), Kit
patent: 4603112 (1986-07-01), Paoletti et al.
patent: 4769331 (1988-09-01), Roizman et al.
Post et al. (1981), Cell 24: 555-65.
Mocarski et al. (1980), Cell 22: 243-55.
Roizman et al. (1982), 17, Int'l Congress on Herpes Virus of Man and Animal, Develop. Biol. Standard 52: 287-304.
Watson et al. (1984), J. Invest Dermatol., 83 Suppl. 1, 102-11 (CA101(17):145077u).
Barahona et al., Laboratory Animal Science, 26(6), Part II, 1104-1112 (1976).
Centifanto-Fitzgerald, The Role of Viruses in Human Cancer, vol. II, Girald et al., eds, Elsevier Science Publishers, BV. 25-36 (1984).
Hall et al., Vaccine, 4, 138-150 (1986).
Hsuing et al., Reviews of Infectious Diseases, 6(1), 33-50 (1984).
Melendez et al., Laboratory Animal Care, 19(1), 38-45 (1969).
Meignier et al., Vaccines, 87, Cold Spring Harbor Laboratory, Chanock et al., eds., 368-373 (1987).
Scriba, Infection and Immunity, 12(1), 162-165 (1975).
Stanberry et al., J. Infection Disease, 146(3), 397-404 (1982).
Centifanto-Fitzgerald et al, J. Exp. Med., vol. 155, pp. 475-489 (1982).
Chang et al, J. Bacteriol, vol. 134 at 1141 (1978).
Hayward et al, Proc. Nat. Acad. Sci., USA, vol. 72, No. 11 at 4243-4247 (1975).
Kousoulas et al., Virology, vol. 135, pp. 379-395 (1984).
Kristie et al., Proc. Natl. Acad. Sci., USA, vol. 81 at 4065-4069 (1984).
Morse et al, "Anatomy of Herpes Simplex Virus (HSV) DNA:X. Mapping of Viral Genes by Analysis of Polypeptides and Functions Specified by HSV-1.times.HSV-2 Recombinants", J. Virol., vol. 26, No. 2 at 389-410 (May 1978).
Poffenberger et al, Proc. Natl. Acad. Sci., USA, vol. 80, pp. 2690-2694 (1983).
Poffenberger and Roizman, J. Virol., vol. 53, pp. 587-595 (1985).
Post et al., Proc. Natl. Acad. Sci., USA, vol. 77, No. 7 at 4201-4205 (1980).
Roizman et al., Virology, vol. 133, pp. 242-247 (1984).
Wadsworth et al., J. Virol, vol. 15, No. 6 at 1487-1497 (1979).

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