Recombinant herpes simplex viruses vaccines and methods

Details Recombinant herpes simplex viruses vaccines and methods Recombinant herpes simplex viruses vaccines and methods

1990-09-10

1994-07-12

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

530350, 4352351, 435 691, 4351721, 536 2372, 4242311, A61K 3912, C12P 2106, C12N 1500, C07H 1512

Patent

active

053286880

ABSTRACT:
A virus is disclosed which is rendered avirulent by prevention of expression of an active product of a gene which is designated as .gamma..sub.1 34.5, which maps in the inverted repeats flanking the long unique sequence of herpes simplex virus DNA, and which is not essential for viral growth in cell culture. Viruses from which the gene was deleted or which carried stop codons are totally avirulent on intracerebral inoculation of mice.

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