Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Reexamination Certificate
2006-08-29
2006-08-29
Foley, Shanon (Department: 1648)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
C530S344000
Reexamination Certificate
active
07098309
ABSTRACT:
The present invention provides an improved rHBsAg that exhibits a higher antigenicity and immunogenicity than that previously known in the art. A method of making the improved rHBsAg is also provided. The improved HBsAg is used to provide vaccines with lower amounts of active ingredient, vaccines with higher immunogenicity and combination vaccines which produce and protective immunization against infection by hepatitis B virus and other infectious agents.
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Abraham Dicky G.
Gervais David P.
Gimenez Juan
Sitrin Robert
Zhao Qinjian
Foley Shanon
Merck & Co. , Inc.
Tribble Jack L.
Yablonsky Michael D.
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