Recombinant gelatin-like proteins for use as plasma expanders

Details Recombinant gelatin-like proteins for use as plasma expanders Recombinant gelatin-like proteins for use as plasma expanders

2002-03-06

2008-12-02

Desai, Anand U (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S391700

Reexamination Certificate

active

07459431

ABSTRACT:
The invention relates to compositions suitable for plasma substitution comprising as a plasma expander a recombinant gelatin-like protein. Characteristic is that the gelatin-like protein essentially is free of hydroxyproline. This absence of hydroxyproline prevents the composition from gelling and thus allows the use of high-molecular weight proteins in order to establish a suitable colloid osmotic pressure. Specific advantage of the gelatin-like proteins is that these avoid the risk of anaphylactic shock that exists in conjunction with the use of commercially available preparations.

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patent: WO 01/34646 (2001-05-01), None
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Haemaccel package insert (published Aug. 28, 1992).
Wootton, J., “Non-globular domains in protein sequences: automated segmentation using complexity measures”, Computers Chem. vol. 18, No. 3, pp. 269-285, 1994.

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