Recombinant gas vesicles and uses thereof

Details Recombinant gas vesicles and uses thereof Recombinant gas vesicles and uses thereof

1996-12-05

1998-10-20

Guzo, David

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4241901, 4242011, 4242041, 4242071, 4242081, 4242341, 514 2, 530350, A61K 3921, A61K 3902, A61K 39295, C07K 14195

Patent

active

058243097

ABSTRACT:
The invention features a composition that includes a substantially pure recombinant gas vesicles which have at least one heterologous peptide inserted into at one of their structural proteins. The recombinant gas vesicle, when administered to a mammal, is capable of eliciting antibodies which specifically bind to the heterologous peptide. The heterologous peptide can be any peptide against which one wishes to raise antibodies, e.g., a peptide found in the gp12O protein of human immunodeficiency virus (HIV).

REFERENCES:
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J.S. Allan, "Major Glycoprotein Antigens Taht Induce Antibodies in AIDS Patients Are Encoded by HTLV-III" Science 228:1091-1094, 1985.
Muster et al., "A Conserved Neutralizing Epitope on gp41 of Human Immunodeficiency Virus Type 1" J. of Virology 67(11):6642-6647, 1993.
Blaseio et al., "Transformation of Halobacterium halobium: Development of vectors and investigation of gas vesicle synthesis" Proc. Natl., Acad. Sci. USA 87:6772-6776, 1990.
DasSarma et al., "Wild-Type Gas Vesicle Formation Requires at Least Ten Genes in the gvp Gene Cluster . . . " J. of Bacteriology 176(24):7646-7652, 1994.
DasSarma et al., "Gas Vesicle Proteins and Genes" Mol. Biol. 12:93-98, 1993.
Halladay et al., "The Rightward Gas Vesicle Operon in Halobacterium Plasmid pNRC100: . . . " J. of Bacteriology 175(3):684-692, 1993.
Halladay et al., Genetic transformation of a halophilic archaebacterium with a gas vesicle gene cluster restores.
Jones et al., "Structure and organization of the gas vesicle gene cluster on the Halobacterium Halobium plasmid pNRC100" Gene 102:117-122, 1991.

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