Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1994-03-22
1997-11-25
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
530351, A61K 3821, C07K 1457
Patent
active
056909250
ABSTRACT:
The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties characteristic of native human gamma interferon. The amino acid sequence of such an interferon comprises, from the N-terminus: ##STR1## wherein X is a methionine residue or hydrogen and Y is a glutamine residue or, where X is hydrogen, Y is either a glutamine or a pyroglutamate residue.
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Gray Patrick W.
Rinderknecht Ernst H.
Genentech Inc.
Wax Robert A.
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