Recombinant gamma interferons having enhanced stability and meth

Details Recombinant gamma interferons having enhanced stability and meth Recombinant gamma interferons having enhanced stability and meth

1984-02-27

1989-08-08

Martinell, James

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

435 68, 435 70, 435 91, 4351721, 4351723, 4352402, 4352523, 435320, 43525233, 530351, 536 27, 935 9, 935 10, 935 11, 935 27, 935 29, 935 66, 935 72, C12N 100, C12N 1500, C12N 500, C12N 120, C12P 2100, C12P 2102, C12P 1934, C07H 2104, C07K 1300

Patent

active

048552380

ABSTRACT:
The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties characteristic of native human gamma interferon. The amino acid sequence of such an interferon comprises, from the N terminus: ##STR1## wherein X is a methionine residue or hydrogen and Y is a glutamine residue or, where X is hydrogen, Y is either a glutamine or a pyroglutamate residue.

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