Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated to proteinaceous toxin or fragment thereof
Reexamination Certificate
2008-05-08
2011-10-25
Minnifield, Nita M (Department: 1645)
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated to proteinaceous toxin or fragment thereof
C435S007200
Reexamination Certificate
active
08043621
ABSTRACT:
The present invention relates to a polynucleotide construct encoding a fusion protein consisting of a domain which binds the immunoglobulin Fc region, genetically fused to a truncated form ofPseudomonasexotoxin A (PE). In particular, the invention discloses the fusion protein, ZZ-PE38, and further provides immunotoxins, formed from complexes of the fusion protein with antibodies for targeted cell killing.
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Benhar Itai
Mazor Yariv
Gangle Brian J
Minnifield Nita M
Ramot at Tel Aviv University Ltd.
Winston & Strawn LLP
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