Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Reexamination Certificate
2011-04-19
2011-04-19
Saidha, Tekchand (Department: 1652)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
C424S094100, C536S023100
Reexamination Certificate
active
07927603
ABSTRACT:
A recombinant fusion enzyme repairs DNA damaged by UV radiation, and the method of preparing recombinant fusion enzyme. The method includes the fusion of an enzyme coded by a gene isolated fromMicrococcus luteusand a stabilizing peptide having the amino acid sequence described in SEQ ID NO 2. A treatment method intended to repair DNA lesions produced in cells exposed to UV radiation and to repair cell anomalies or lesions produced by sun exposure. Such treatment consists of the administration of a effective amount of recombinant fusion enzyme, or a vector containing the gene coding to the recombinant fusion enzyme, to patients requiring such treatment.
REFERENCES:
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Biochimica et Biophysica Acta, 698 (1982) 287-294; pp. 287-295; N. V. Tomilin et al. An Analysis of the Repair Processes in Ultraviolet IrradiatedMicrococcus luteusUsing . . . .
Base Excision Repair of DNA Damage, edited by Ian D. Hickson; 1997 Landes Bioscience; pp. 31-44; Serge Boiteux et al.; Repair of Oxidized Purines in DNA.
Basílico Guillermo
Kerner Nestor Alberto
Seigelchifer Mauricio
Lackenbach & Siegel LLP
Saidha Tekchand
LandOfFree
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