Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...
Patent
1995-06-07
1998-12-15
Adams, Donald E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant virus encoding one or more heterologous proteins...
4241881, 4242081, 4351723, 4353201, 536 2372, A61K 3912, A61K 3921, C12N 1500, C07H 2104
Patent
active
058493034
ABSTRACT:
The present invention pertains to the prevention or lessening of disease in cats caused by Feline Immunodeficiency Virus (FIV). Prevention or lessening of disease is understood to mean the amelioration of any symptoms, including immune system disruptions, that result from FIV infection. The invention provides recombinant proteins produced in a baculovirus expression system having at least one internal gene comprising a DNA sequence that encodes either the entire FIV env region (ENV-ABC), or a DNA sequence consisting of viral nucleotides 6252-8469 of FIV env (ENV-AB), a DNA sequence consisting of viral nucleotides 6252-6722 and 8264-9140 of FIV env (ENV-AC), or immunogenic fragments of any of the foregoing either singly or in combination. By immunogenic fragment is meant any portion of the coding sequence of FIV env polypeptides that induces a beneficial immune response in cats. In another embodiment, the invention encompasses vaccines that comprise one or more of the baculovirus-expressed recombinant FIV proteins described above, with a pharmaceutically acceptable carrier or diluent and a pharmaceutically acceptable adjuvant. In yet another aspect, the invention provides methods for preventing or lessening disease caused by FIV, which is carried out by administering to a feline in need of such treatment the vaccines described above.
REFERENCES:
FIV Vaccine Studies. II. Coinical Findings, Hematological changes and Kinetics of Blood Lymphocyte Subsets--R. Hofmann-Lehmann, E. Holznagel, A. Aubert, K. Bauer-Pham & H. Lutz--Veterinary Immunopatholgy 46 (1995) 115-125.
FIV Vaccine Studies, I. Immune response to recombinant FIB env Gene Products and Outcome after Challenge infection--H. Lutz, R. Hofmann-Lehmann, K. Bauer-Pham, E. Holznagel, F. Tozzini, M. Bendinelli, G. Ruebel, A. Aubert, D. Davis--Veterinary Immunology & Immunology & Immunopathology 46 (1995) 103-113.
Expression of Feline Immunodeficiency Virus gag and env Precursor Proteins in Spodoptera Frugiperda Cells and Their Use in Immunodiagnosis--Ernst J. Verschoor, Arno L.W. van Vliet, Herman FD. Egberink, Wim Hesselink, Marian C. Horzinek & Anthony de Ronde--Journal of Clinical Microbiology, Sep., 1993, p. 2350-2355 vol. 31, No. 9.
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Haynes, B., 1993, Science 260:1279-1286.
Sparger, E., 1993, "Current thoughts on feline immunodeficiency virus infection" in Feline Infections Diseases, Hoskins et al., eds., W.B. Saunders Co., Philadelphia, pp. 173-191.
Lutz et al., 1995, Vet. Immunol. Immunopath. 46:103-113.
Siebelink et al., 1995, J. Virol. 69:3704-3711.
Chu Hsien-Jue
Wasmoen Terri
Adams Donald E.
American Home Products Corporation
Parkin Jeffrey S.
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