Recombinant feline herpesvirus vaccine

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...

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4241841, 4241851, 4242291, 4242051, 4351723, 435 693, 435236, 4352401, A61K 3912, A61K 39245

Patent

active

057831920

ABSTRACT:
The present invention is concerned with a Feline herpesvirus (FHV) mutant comprising a heterologous gene introduced into an insertion-region of the FHV genome.
The invention also relates to a vector vaccine comprising such an FHV mutant which expresses a heterologous polypeptide derived from a feline pathogen and induces an adequate immune response in an inoculated host against both FHV and the feline pathogen.

REFERENCES:
P.A. Rota et al., "Physical Characterization of the Genome of Feline Herpes-virus-1," Virology, vol. 154, No. 1, pp. 168-179, Oct. 15, 1986, New York, USA.
G.E. Cole et al., "Recombinant Feline Herpesvirus Expressing Feline Leukimia Virus Envelope and Gag Proteins," Journal of Virology, vol. 64 No. 10, pp. 4930-4938, Oct. 1990.
L. Nicholson et al., "The Nucleotide Sequnece of the Equine Herpesvirus 4 gC Gene Homologue," Virology, vol. 179, No. 1, pp. 378-387, Nov. 1990, NY.
G.P. Allen et al., "Characterization of an Equine Herpesvirus Type 1 Gene Encoding a glycoprotein (gp13) with Homology to HSV Glycoprotein C," Journal of Virology, vol. 62, No. 8, pp. 2850-2858, Aug. 1988.

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