Recombinant Factor VIIIC fragments

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4351723, 4353201, 530383, 530350, 536 27, C12N 1510, C12N 2100, C07H 1512, C07K 1300

Patent

active

051496372

ABSTRACT:
New fragments of the Factor VIII procoagulant protein (Factor VIIIC) are disclosed. These fragments have an Mr value of 88,000 d or 49,000 d or extend from amino acid residues 1974 to 2332 or 2052 to 2332. These fragments have use in the treatment of patients who have developed antibodies which inhibit Factor VIII.

REFERENCES:
patent: 4649132 (1987-03-01), Zimmerman
patent: 4757006 (1988-07-01), Toole
patent: 4980456 (1990-12-01), Scandella

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