Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-04-06
1990-12-25
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530350, 530380, 530382, 530384, 530395, 530806, 530529, 435 692, 435 696, 4351723, 514 2, 514 8, 514 21, C07K 1300, C12N 1512, A61K 3702
Patent
active
049804561
ABSTRACT:
New fragments of the Factor VIII procoagulant protein (Factor VIIIC) are disclosed. These fragments have an Mr value of 88,000 d or 49,000 d or extend from amino acid residues 1974 to 2332 or 2052 to 2332. These fragments have use in the treatment of patients who have developed antibodies which inhibit Factor VIII.
REFERENCES:
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patent: 4657894 (1987-04-01), Zimmerman et al.
patent: 4749780 (1988-06-01), Andersson et al.
patent: 4769336 (1988-09-01), Zimmerman et al.
patent: 4886876 (1989-12-01), Zimmerman et al.
Nachman et al., Bioch Biophys Res. Comm, 92(4), p. 1208, (1980).
Wood, et al., Nature, 312:330-337 (1984).
Drohan William N.
Fulcher Carol A.
Scandella Dorothea H.
Zimmerman Theodore S.
Balogh Imre
Jervis Herbert H.
Kushan Jeff
Moskowitz Margaret
Rorer Biotechnology Inc.
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