Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-09-01
1994-08-30
Hill, Jr., Robert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 536 235, C12P 2106, C12N 120, C12N 1500, C07H 1700
Patent
active
053427645
ABSTRACT:
Cloning and expression of the gene encoding human phospholipase inhibitory protein (hPIP) permits production of an anti-inflammatory protein in practical quantities using recombinant techniques.
REFERENCES:
patent: 5264550 (1993-11-01), Johnson et al.
Hong et al., "Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids" Proc. Natl. Acad. Sci. USA (1976) 73(5):1730-1734.
Hirata, F., "The regulation of lipomodulin, a phospholipase inhibitory protein, in rabbit neutrophils by phosphorylation" J. Biol. Chem. (1981) 256(15):7730-7733.
Blackwell et al., "Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids" Nature (1980) 287:147-149.
Russo-Marie et al., "Dexamethasone-induced inhibition of prostaglandin production does not result from a direct action on phospholipase activities but is mediated through a steroid-inducible factor" Biochimica et Biophysica Acta (1982) 712:177-185.
Hirata et al., "A phospholipase A.sub.2 inhibitory protein in rabbit neutrophils induced by glucocorticoids" Proc. Natl. Acad. Sci. USA (1980) 77(5):2533-2536.
Rothhut et al., "Further characterization of the glucocorticoid-induced antiphospholipase protein renocortin" Biochem. Biophys. Res. Commun. (9183) 117(3):878-884.
Hirata et al., "Identification of several species of phospholipase inhibitory protein(s) by radioimmunoassay for lipomodulin" Biochem. Biophys. Res. Commun. (1982) 109(1):223-230.
Johnson et al., "Glucocorticoid action: a mechanism involving nuclear and non-nuclear pathways" Brit. J. Dermatol. (1982) 107(Suppl 23):6-23.
Hattori et al., "Differentiation of a histiocytic lymphoma cell line by lipomodulin, a phospholipase inhibitory protein" Biochem. Biophys. Res. Commun. (1983) 111(2):551-559.
Johnson Lorin K.
Longenecker John P.
Hill Jr. Robert J.
Kemmerer Elizabeth C.
Scios Nova Inc.
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