Recombinant eukaryotic plasmids containing allergen-gene and use

Details Recombinant eukaryotic plasmids containing allergen-gene and use Recombinant eukaryotic plasmids containing allergen-gene and use

1996-07-12

1999-09-28

Chambers, Jasemine C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4353201, 4351723, 435375, A61K 4800, C12N 1579

Patent

active

059588918

ABSTRACT:
The present invention relates to recombinant eukaryotic plasmids comprising an eukaryotic expression vector and an allergen gene for the prevention and/or treatment of allergic diseases. When the recombinant vector containing allergen-gene is administered to an individual in need of such prevention and/or treatment by intramuscular injection, intranasal delivery or intratracheal delivery, the production of allergen-specific IgE synthesis can be inhibited. The invention also relates to the pharmaceutical compositions comprising the recombinant vector for use in the the prevention and/or treatment of allergic diseases and the production of allergen-specific IgE synthesis. A method for the prevention and/or treatment of allergic diseases is also provided.

REFERENCES:
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5589466 (1996-12-01), Felgner et al.
Yang, et al., Biochemical and Biophysical Research Communications, 212(3):1029-1039, Jul. 26, 1995.
Hsu et al., Nature Medicine, 2(5):540-544, May, 1996.
Dittrich et al., Bio/Technology, 12(6):614-618, 1994.
Campbell et al., J. Immunological Methods, 188:73-78, 1995.
Raz et al., Proc. Natl. Acad. Sci. USA, 93:5141-5145, May, 1996.
Hsu et al., International Immunology, 8(9):1405-1411, 1996.
Raz et al., J. Allergy and Clinical Immunology, 97(1 Part 3):362, 1996.
Sporik et al., 1990, "Exposure to house dust mite allergen (DER p 1) and the development of asthma in childhood: a prospective study" New England J. Med. 323:502-507.
Platt-Mills et al., 1992, "Dust mite allergens and asthma: a report of the 2nd international workshop" J. Allergy Clin. Immunol. 89:1046-1060.
Burrows et al., 1989, Association of asthma with serum IgE levels and skin-test reactivity to allergens: New England J. Med. 320:271-277.
Sears et al., 1991, "Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children" New England J. Med. 325:1067-1071.
Hsieh, K.H., 1984, Changes of lymphoproliferative responses of T cell subsets to allergen and mitogen after hyposensitization in asthmatic children: J. Allergy Clin. Immunol. 74:34-40.
Gonzalez et al., 1987, "Allergen-induced recruitment of bronchoaveolar helper (OKT4) and suppressor (OKT8) T-cells in asthma" Am. Rev. Respir. Dis.136:600-604.
Sedgwick et al., 1985, "Induction of IgE secreting cells and IgE isotype-specific suppressor cells in the respiratory lymph nodes of rats in response to antigen inhalation" Cell Immunol. 94:182-194.
Kemeny et al., 1991, "Role of CD8 T-cells in rat IgE responses" Int. Arch. Allergy Appl. Immunol. 94:99-101.
McMenamin et al., 1993, "The natural immune response to inhaled soluble protein antigens involves major histocompatability complex (MHC) class-restrictted CD8+ T cell-mediated but not MHC Class II-restricted CD4+ T cell-dependent immune deviation resultng in selective suppression of immunoglobulin production" J. Exp. Med. 178:889-899.
Renz et al., 1994, "Inhibition of IgE production and normalization of airiway responsiveness by sensitized CD8 T cells in a mouse model of allergen-induced sensitization" J. Immunol. 152:351-360.
Wolff et al., 1990, "Direct gene transfer into mouse muscle in vivo" Science 247:1465-1468.
Tang et al., 1992, "Genetic immunization is a simple method for illiciting an immune response" Nature 356:152-154.
Holt et al., 1987, "Suppression of IgE responses following antigen inhalation: a natural homeostatic mechanism which limits sensitization to aeroallergens" Immunol. Today 8:14-18.
Kemeny et al., 1994, "Immune regulation: a new role for the CD8+ T cell" Immunol. Today 15:107-110.
Keh-Liang Lin et al., 1994, "Allergens, IgE, Mediators, inflammatory mechanisms: Characterization of Der p V allergen, cDNA analysis, and IgE-mediated reactivity to the recombinant protein" J. Allergy Clin. Immunol. 94:989-996.

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