Recombinant equine herpesviruses

Details Recombinant equine herpesviruses Recombinant equine herpesviruses

1994-02-17

1998-04-21

Guzo, David

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

4353201, 435236, C12N 701, C12N 704, C12N 1586

Patent

active

057416966

ABSTRACT:
The present invention relates to a non-naturally occurring, recombinant equine herpesvirus. The invention also relates to a recombinant equine herpesvirus capable of replication which comprises viral DNA from a species of equine herpesvirus and foreign DNA, the foreign DNA being inserted into the equine herpesviral DNA at a site which is not essential for replication of the equine herpesvirus. The invention also relates to DNA encoding the US2 protein of an equine herpesvirus. The invention relates to homology vectors for producing recombinant equine herpesviruses which produce recombinant equine herpesviruses by inserting foreign DNA into equine herpesviral DNA. The invention further relates to a method of producing a fetal-safe, live recombinant equine herpesvirus.

REFERENCES:
patent: 5292653 (1994-03-01), Kit et al.
Saul Kit, "Genetically Engineered Pseudorabies and Infectious Bovine Rhinotrachetis Virus Vaccines", In: Technological Advances in Vaccine Development, pp. 183-195, 1988, Alan R. Liss, Inc.
Colle et al. "Open Reading Frames Encoding a Protein Kinase, Homolog of Glycoprotein gX of Pseudorabies Virus, and a Novel Glycoprotein Map within the Unique Short Segment of Equine Herpesvirus Type 1", Virology, vol. 188, pp. 545-557, May 1992.
Meignier et al, "Virulence of and Establishment of Latency by Genetically Engineered Deletion Mutants of Herpes Simplex Virus 1", Virology, vol. 162, 1988, pp. 251-254.
Shih et al. "Expression of Hepatitis B Virus S gene by Herpes Simplex Virus Type 1 Vectors Carrying .gamma.-and .beta.-regulated Gene chimeras", PNAS, vol. 81, pp. 5867-5870, Sep. 1984.
Audonnet et al. "Equine Herpesvirus Type 1 Unique Short Fragment Encodes Glycoproteins with Homology to Herpes Simplex Virus Type 1 gD, gI and gE", J. Gen. Virol., vol. 71, 1990, pp. 2969-2978.
B.S. Crabb, et al., "Identification of Equine Herpesvirus 4 Glycoprotein G: A Type-Specifice, Secreted Glycoprotein", Virology (1992) 190: 143-154 (Exhibit 5).
B.S. Crabb, et al., "Epitopes of Glycoprotein G of Equine Herpesvirus 4 and Located near the C Terminal Elicit Type-Specific Antibody Responses in the Natural Host", J. Virol. (1993) 67: 6332-6338 (Exhibit 6).
A.A. Cullinane, et al., "The DNA sequence of the equine herpesvirus 4 gene encoding glyxoprotein gp 17/18, the homologue of herpes simplex virus glycoprotein gD", J. Gen. Virol. (1993) 74: 1959-1964 (Exhibit 7).
H.S. Nagesha, et al., "Analysis of the nucleotide sequence of filve genes at the left end of the unique short region of the equine herpesvirus 4 genome", Arch. Virol. (1993) 128: 143-154 (Exhibit 8).

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