Recombinant double-stranded RNA phages and uses thereof

Details Recombinant double-stranded RNA phages and uses thereof Recombinant double-stranded RNA phages and uses thereof

2003-08-20

2008-08-05

Campell, Bruce (Department: 1648)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Reexamination Certificate

active

07407790

ABSTRACT:
The present invention provides recombinant double stranded RNA phages (rdsRP) that express dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phages are useful for the expression of dsRNA expression cassettes encoding passenger genes, such as, but not restricted to, vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Methods are provided to deliver a recombinant dsRNA phage to eukaryotic cells and tissues, either by direct administration, formulated in lipid or polylactidecoglycolide, or by utilizing a bacterial vaccine vector.

REFERENCES:
patent: 5877159 (1999-03-01), Powell et al.
Abacioglu, Y.H., Fouts, T.R., Laman, J.D. et al. Epitope mapping and topology of baculovirus-expressed HIV-1 gp160 determined with a panel of murine monoclonal antibodies.AIDS Res. Hum. Retrovir. 1994, 10(4), 371-381.
Agwale, S.M., Shata, M.T., Reitz, M.S., Jr. et al. A Tat subunit vaccine confers protective immunity against the immune-modulating activity of the human immunodeficiency virus type-1 Tat protein in mice.Proc Natl Acad Sci U S A2002, 99(15), 10037-10041.
Andre, S., Seed, B., Eberle, J., Schraut, W., Bultmann, A. & Haas, J. Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage.J Virol1998, 72(2), 1497-1503.
Baba, T.W., Liska, V., Hofmann-Lehmann, R. et al. Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection.Nat. Med. 2000, 6(2), 200-206.
Bagley, K.C., Shata, M.T., Onyabe, D.Y., DeVico, A.L., Fouts, T.R., Lewis, G.K. & Hone, D.M. Immunogenicity of DNA vaccines that direct the coincident expression of the 120 kDa glycoprotein of human immunodeficiency virus and the catalytic domain of cholera toxin.Vaccine2003, 21, 3335-3341.
Balasuriya, U.B., Heidner, H.W., Davis, N.L. et al. Alphavirus replicon particles expressing the two major envelope proteins of equine arteritis virus induce high level protection against challenge with virulent virus in vaccinated horses.Vaccine2002, 20(11-12), 1609-1617.
Bamford, D.H. & Palva, E.T. Structure of the lipid-containing bacteriophage phi 6. Disruption by Triton X-100 treatment.Biochim Biophys Acta1980, 601(2), 245-259.
Berger, H. & Kennedy, K. Physical measurements on the lipid-containing bacteriophage phi 6.Biochim Biophys Acta1980, 633(1), 68-76.
Berglund, P., Fleeton, M.N., Smerdou, C. & Liljestrom, P. Immunization with recombinant Semliki Forest virus induces protection against influenza challenge in mice.Vaccine1999, 17(5), 497-507.
Brinster, C., Chen, M., Boucreux, D. et al. Hepatitis C virus non-structural protein 3-specific cellular immune responses following single or combined immunization with DNA or recombinant Semliki Forest virus particles.J Gen Virol2002, 83(Pt 2), 369-381.
Caley, I.J., Betts, M.R., Irlbeck, D.M. et al. Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector.J Virol1997, 71(4), 3031-3038.
Conley, A.J., Kessler, J.A., II, Boots, L.J. et al. The consequence of passive administration of an anti-human immunodeficiency virus type 1 neutralizing monoclonal antibody before challenge of chimpanzees with a primary virus isolate.J. Virol.1996, 70(10), 6751-6758.
Conry, R.M., LoBuglio, A.F., Wright, M. et al. Characterization of a messenger RNA polynucleotide vaccine vector.Cancer Res1995, 55(7), 1397-1400.
Dalemans, W., Delers, A., Delmelle, C. et al. Protection against homologous influenza challenge by genetic immunization with SFV-RNA encoding Flu-HA.Ann N Y Acad Sci1995, 772, 255-256.
Davis, N.L., Brown, K.W. & Johnston, R.E. A viral vaccine vector that expresses foreign genes in lymph nodes and protects against mucosal challenge.J Virol1996, 70(6), 3781-3787.
DeVico, A.L., Rahman, R., Welch, J. et al. Monoclonal antibodies raised against covalently crosslinked complexes of human immunodeficiency virus type 1 gp120 and CD4 receptor identify a novel complex-dependent epitope on gp 120.Virol. 1995, 211(2), 583-588.
Emini, E.A., Schleif, W.A., Nunberg, J.H. et al. Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody.Nature1992, 355(6362), 728-730.
Emini, E.A., Nara, P.L., Schleif, W.A. et al. Antibody-mediated in vitro neutralization of human immunodeficiency virus type 1 abolishes infectivity for chimpanzees.J. Virol. 1990, 64(8), 3674-3678.
Fleeton, M.N., Sheahan, B.J., Gould, E.A., Atkins, G.J. & Liljestrom, P. Recombinant Semliki Forest virus particles encoding the prME or NS1 proteins of louping ill virus protect mice from lethal challenge.J Gen Virol1999, 80 ( Pt 5), 1189-1198.
Fouts, T.R., Lewis, G.K. & Hone, D.M. Construction and characterization of aSalmonella typhi-based human immunodeficiency virus type 1 vector vaccine.Vaccine1995, 13(6), 561-569.
Fouts, T.R., Tuskan, R., Godfrey, K. et al. Expression and characterization of a single-chain polypeptide analogue of the human immunodeficiency virus type 1 gp120-CD4 receptor complex.J Virol2000, 74(24), 11427-11436.
Galan, J.E., Nakayama, K. & Curtiss, R.d. Cloning and characterization of theasdgene ofSalmonella typhimurium: use in stable maintenance of recombinant plasmids inSalmonellavaccine strains.Gene1990, 94(1), 29-35.
Gottlieb, P., Strassman, J., Qiao, X., Frilander, M., Frucht, A. & Mindich, L. In vitro packaging and replication of individual genomic segments of bacteriophage phi 6 RNA.J Virol1992, 66(5), 2611-2616.
Gottlieb, P., Strassman, J., Frucht, A., Qiao, X.Y. & Mindich, L. In vitro packaging of the bacteriophage phi 6 ssRNA genomic precursors.Virology1991, 181(2), 589-594.
Gottlieb, P., Strassman, J., Qiao, X.Y., Frucht, A. & Mindich, L. In vitro replication, packaging, and transcription of the segmented double-stranded RNA genome of bacteriophage phi 6: studies with procapsids assembled from plasmid-encoded proteins.J Bacteriol1990, 172(10), 5774-5782.
Gottlieb, P., Metzger, S., Romantschuk, M. et al. Nucleotide sequence of the middle dsRNA segment of bacteriophage phi 6: placement of the genes of membrane-associated proteins.Virology1988, 163(1), 183-190.
Haas, J., Park, E.C. & Seed, B. Codon usage limitation in the expression of HIV-1 envelope glycoprotein.Curr Biol1996, 6(3), 315-324.
Haigwood, N.L., Watson, A., Sutton, W.F. et al. Passive immune globulin therapy in the SIV/macaque model: early intervention can alter disease profile.Immunol. Lett. 1996, 51(1-2), 107-114.
Hofmann-Lehmann, R., Vlasak, J., Rasmussen, R.A. et al. Postnatal passive immunization of neonatal macaques with a triple combination of human monoclonal antibodies against oral simian-human immunodeficiency virus challenge.J. Virol. 2001, 75(16), 7470-7480.
Hoogstraten, D., Qiao, X., Sun, Y., Hu, A., Onodera, S. & Mindich, L. Characterization of phi8, a bacteriophage containing three double-stranded RNA genomic segments and distantly related to phi6.Virology2000, 272(1), 218-224.
Jang, S.K., Krausslich, H.G., Nicklin, M.J., Duke, G.M., Palmenberg, A.C. & Wimmer, E. A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation.J Virol1988, 62(8), 2636-2643.
Johnson, M.D., 3rd & Mindich, L. Plasmid-directed assembly of the lipid-containing membrane of bacteriophage phi 6.J Bacteriol1994, 176(13), 4124-4132.
Kakitani, H., Iba, H. & Okada, Y. Penetration and partial uncoating of bacteriophage phi 6 particle.Virol.1980, 101(2), 475-483.
Kang, C.Y., Hariharan, K., Nara, P.L., Sodroski, J. & Moore, J.P. Immunization with a soluble CD4-gp120 complex preferentially induces neutralizing anti-human immunodeficiency virus type 1 antibodies directed to conformation-dependent epitopes of gp120.J. Virol. 1994, 68(9), 5854-5862.
Kieft, J.S., Zhou, K., Jubin, R., Murray, M.G., Lau, J.Y. & Doudna, J.A. The hepatitis C virus internal ribosome entry site adop

Affiliated with

Also associated with

Rating

Recombinant double-stranded RNA phages and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Recombinant double-stranded RNA phages and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant double-stranded RNA phages and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3995000