Recombinant double-stranded RNA phage, and use of the same

Details Recombinant double-stranded RNA phage, and use of the same Recombinant double-stranded RNA phage, and use of the same

2006-02-24

2009-08-04

Low, Christopher S. F. (Department: 1636)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093600, C424S093100, C435S252500, C435S252300, C435S320100, C435S069100, C536S023100, C536S023720

Reexamination Certificate

active

07569219

ABSTRACT:
A recombinant double stranded RNA (dsRNA) phage expresses dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phage are useful for the expression of dsRNA expression cassettes encoding passenger genes, such as, but not restricted to, vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Methods are provided to deliver recombinant dsRNA phage to eukaryotic cells and tissues, either by direct administration, formulated in lipid or polylactide-coglycolide, or by utilizing a bacterial vaccine vector.

REFERENCES:
Poranen, Virus Research, 2004, vol. 101, pp. 93-100.
Mindich et al., J. Bacteriology, 1999, vol. 181, No. 15, pp. 4505-4508.
Mindich, Microbiology and Molecular Biology Reviews, 1999, vol. 63, No. 1, pp. 149-160.

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