Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide
Patent
1987-01-08
1988-08-23
Martinell, James
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using tissue cell culture to make a protein or polypeptide
435 68, 435 71, 435 91, 4351721, 4351723, 4352401, 4352402, 435243, 435253, 435255, 435256, 435320, 536 27, 935 11, 935 27, 935 66, 935 72, 935 73, C12P 2102, C12P 2100, C12P 2104, C12P 1934, C12N 1500, C12N 500, C12N 100, C12N 120, C12N 116, C12N 118, C07H 2104
Patent
active
047660694
ABSTRACT:
The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically, the subject invention comprises the cloning of a cDNA synthesized by reverse transcription of poly(A)RNA isolated from adherent human monocytes stimulated with bacterial endotoxin. Human IL-1 is useful to induce the production of IL-2 by activated T-cells; it also acts on B-cells and NK-cells.
REFERENCES:
Windle et al, "Induction of Interleukin 1 Messenger RNA and Translation in Oocytes", J. Immunol. 132: 1323 (1984).
Okayama et al, "A cDNA Cloning Vector that Permits Expression of cDNA Inserts in Mammalian Cells", Molec. Cell. Biol. 3: 280 (1983).
Roberts et al, "A General Method for Maximizing the Expression of a Cloned Gene", Proc. Natl. Acad. Sci. USA 76: 760 (1979).
Dinarello, C. A., Rev. Inf. Dis. (1984) 6: 51-95.
Rosenwasser, L. J., Dinarello, C. A., and Rosenthal, A. S. (1979), J. Exp. Med. 150: 709-714.
Rosenwasser, L. J. and Dinarello, C. A. (1981), Cell. Immunol. 63: 134-142.
Murphy, P. A., Simon, P. L., and Willoughby, W. F. (1980), J. Immunol. 124: 2498-2501.
Kampschmidt, R. F. (1981) in Infection: The Physiologic and Metabolic Responses of the Host (eds. M. C. Powanda and P. G. Canonico 55-74.
Mizel, S. B., Dayer, J. M., Krane, S. M. and Mergenhagen, S. E. (1981), Proc. Natl. Acad. Sci. USA 78: 2474-2477.
Auron Philip E.
Dinarello Charles A.
Rich Alexander
Webb Andrew C.
Wolff Sheldon M.
Martinell James
MIT
New England Medical Center
Saliwanchik David R.
Saliwanchik Roman
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