Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1995-06-07
1999-11-16
Smith, Lynette R. F.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
4353201, 536 243, C07H 2104, C12N 516, C12N 1585
Patent
active
059856572
ABSTRACT:
The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically, the subject invention comprises the cloning of a cDNA synthesized by reverse transcription of poly(A)RNA isolated from adherent human monocytes stimulated with bacterial endotoxin. Human IL-1 is useful to induce the production of IL-2 by activated T-cells; it also acts on B-cells and NK-cells.
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Auron Philip E.
Dinarello Charles A.
Rich Alexander
Webb Andrew C.
Wolff Sheldon M.
Massachusetts Institute of Technology
Nelson Amy J.
New England Medical Center Hospitals
Smith Lynette R. F.
Tufts College
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