Recombinant DNA vectors encoding a 4"-O-isovaleryl acylase deriv

Details Recombinant DNA vectors encoding a 4"-O-isovaleryl acylase deriv Recombinant DNA vectors encoding a 4"-O-isovaleryl acylase deriv

1988-05-13

1991-11-26

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 691, 435 711, 435 72, 435 91, 435119, 435169, 4351721, 4351723, 4352523, 43525235, 4353201, 435886, 536 71, 536 27, 935 9, 935 14, 935 22, 935 29, 935 38, 935 59, 935 60, 935 61, 935 66, 935 76, C12N 1552, C12N 1576, C12N 900

Patent

active

050681893

ABSTRACT:
The carE gene of Streptomyces thermotolerans has been isolated and used to construct recombinant DNA expression vectors. The carE gene encodes 4"-O-isovaleryl acylase activity important in the biosynthesis of a number of useful antibiotics. The carE gene can be used not only to construct recombinant cells with an increased ability to produce the acylase enzyme but also to construct recombinant cells with the ability to produce novel antibiotic compounds.

REFERENCES:
patent: 4935340 (1990-06-01), Baltz et al.
Epp et al., 1987, Gene, 53:73.

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