Recombinant DNA vector encoding human endothelial cell growth fa

Details Recombinant DNA vector encoding human endothelial cell growth fa Recombinant DNA vector encoding human endothelial cell growth fa

1986-03-03

1989-09-19

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

4351723, 4352402, 435256, 435320, 43525231, 43525233, 536 27, 935 11, 935 13, C12P 2102, C12N 1500, C12N 500, C12N 120, C12N 118, C12N 100, C07H 2100

Patent

active

048681130

ABSTRACT:
Endothelial cell growth factor is achieved through the application of recombinant DNA technology to prepare cloning vehicles encoding the ECGF protein and procedures are disclosed for recovering ECGF protein essentially free of other proteins of human origin. The product is useful for, among other purposes, diagnostic applications and as potential in the treatment of damaged blood vessels or other endothelial cell-line structures.

REFERENCES:
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Hunkapiller et al., Methods in Enzymology, vol. 91, pp. 399-413 (1983).
Jaye et al., Nucleic Acids Research, vol. 11, pp. 2325-2335 (1983).
Maciag, T., "Angiogensis", Progress in Hemostasis and Thrombosis, vol. 7, pp. 167-182 (1984).
Maciag, T. et al., "Heparin Binds Endothelial Cell Growth Factor, the Principal Endothelial Cell Mitogen in Bovine Brain", Science, vol. 227, pp. 932-935 (1984).
Schreiber, A. B. et al., "Interaction of Endothelial Cell Growth Factor with Heparin: Characterization of Receptor and Antibody Recognition", Proc. Natl. Acad. Sci., vol. 82, pp. 6138-6142 (1985).
Burgess, W. H. et al., "Multiple Forms of Endothelial Cell Growth Factor", The Journal of Biological Chemistry, vol. 260, pp. 11389-11392 (1985).
Jaye, M. et al., "Modulation of the sis Gene Transcript During Endotheliel Cell Differentiation in Vitro", Science, vol. 228, pp. 882-885 (1985).
Conn, G. et al., "The Isolation and Purification of Two-Anionic Endothelial Cell Growth Factors from Human Brain", Biochemical and Biophysical Research Communications, vol. 124, pp. 262-268 (1984).

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