Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-02-21
2006-02-21
Weber, Jon (Department: 1653)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C530S350000, C536S023100, C424S184100
Reexamination Certificate
active
07001744
ABSTRACT:
Disclosed is a novel vaccine againstEscherichia coli(E. coli) responsible for urinary tract infections. The vaccine is a recombinant chimeric protein which is prepared by linking by genetic recombination a gene encoding an antigenic determinant of uropathogenicE. colito a CTXA2B gene encoding nontoxic A2 and B subunits ofVibrio choleraecholera toxin (CTX) or a LTXA2B gene encoding nontoxic A2 and B subunits ofE. coliheat-labile enterotoxin, wherein a translation product of the CTXA2B or LTXA2B gene serves as an immunogenic adjuvant stimulating mucosal immune responses, expressing the resulting recombinant gene inE. coli, and isolating and purifying an expressed recombinant fusion protein. The recombinant chimeric protein is useful as an oral vaccine with mild side effects and excellent vaccination efficiency against uropathogenicE. coli. Thus, the chimeric vaccine protein can remarkably reduce recurrence of urinary tract infections, prevent occurrence of antibiotic-resistant bacteria, and replace the conventional chemotherapy for urinary tract infections. Also, the chimeric vaccine protein has other advantages of being capable of being produced and commercialized in a short period with relatively low costs, and being easily modified by replacing its genetic constituents with other genes to provide various vaccines.
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Pallesen et al., “Chimeric FimH adhesin of Type 1 fimbriae: a bacterial surface display system for heterologous sequences,” Microbilogy (1995), 141, 2839-2848.
Lee Yong-Hwa
Pyo Suhk-Neung
Jordan and Hamburg LLP
Rooke Agnes
Sungkyunkwan University
Weber Jon
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