Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1987-12-14
1989-12-05
Weimar, Elizabeth C.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4351723, 435183, 43525233, 435254, 435320, 536 27, 935 14, 935 27, 935 34, 935 61, 935 68, 935 72, C12N 1500, C12N 120, C12N 114, C07H 1512
Patent
active
048852520
ABSTRACT:
DNA compounds and recombinant DNA expression vectors that encode and drive expression in recombinant host cells of the isopenicillin N synthetase activity of Aspergillus nidulans are useful to produce isopenicillin N synthetase and to improve the yield of .beta.-lactam-containing antibiotics from antibiotic-producing organisms. The isopenicillin N synthetase gene of A. nidulans can be isolated from plasmid pOGOO4, available from the Northern Regional Research Center under the accession number NRRL B-18171.
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Carr, et al., Gene 48:257, 1986.
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Ingolia Thomas D.
Queener Stephen W.
Skatrud Paul L.
Wiegel Barbara J.
Eli Lilly and Company
Levy Ron K.
Peet Richard C.
Weimar Elizabeth C.
Whitaker Leroy
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