Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1994-08-05
1997-04-22
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435 691, 4353201, 530750, 536 735, C12N 510, C12N 1512
Patent
active
056228619
ABSTRACT:
Provided is the discovery and isolation of a cellular receptor for hepatitis A virus. Also provided is an isolated nucleic acid molecule comprising a nucleic acid encoding a polypeptide having the biological activity of a hepatitis A virus receptor. Also provided are vectors comprising the isolated nucleic acids encoding a hepatitis A virus receptor in host suitable for expression of the nucleic acids encoding the hepatitis receptor, fragments of the hepatitis A virus receptor, or homologs of the hepatitis A virus receptor. Further provided is a nonhuman transgenic animal which expresses a hepatitis A virus receptor, but does not express an endogenous, active hepatitis A virus receptor. Also provided is a method for screening drugs or vaccines utilizing the transgenic animal expressing a hepatitis A virus receptor. Also provided are methods for use of the purified hepatitis A virus receptor, such as separating hepatitis A virus from blood or other samples, detecting the presence of hepatitis A virus in a sample, determining the anti-hepatitis A virus binding of a compound, preventing hepatitis A virus infection in a subject, or treating a subject infected with hepatitis A virus. Also provided are nucleic acids which selectively hybridize with the nucleic encoding the hepatitis A virus receptor of the present invention.
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Totsuka et al. Abstract "Preparation of Monoclonal Antireceptor Antibodies with Inhibitory Effect on Hepatitis A Virus Infection", Japanese Society of Virol., 1988.
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Feinstone Stephen M.
Kaplan Gerardo
The United States of America as represented by the Department of
Ulm John
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