Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1986-09-26
1989-08-29
Brown, Johnnie R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 27, 436813, 436 63, 935 78, 935 9, 4352528, C12Q 168, C07H 2100, C12N 119, C12N 1185
Patent
active
048617105
ABSTRACT:
The invention provides a recombinant cDNA clone encoding cell surface receptor for laminin, as well as a probe and methods of using that probe to diagnose the aggressiveness of a carcinoma or the effectiveness of an agent for treating cancer cells.
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Leptin, M., Nature, vol. 321, 19 Jun. 1986, p. 728.
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Pytela et al., 1985, Proc. Natl. Acad. Sci. U.S.A. 82:5766-5770, "A 125/115-kDa Cell Surface Receptor Specific for Vitronectin Ineracts with the Arginine-Glycine-Aspartic Acid Adhesion Sequence Derived from Fibronectin".
Krotoski et al., 1986, J. Cell Bio 103:1061-1071, "Distribution of a Putative Cell Surface Receptor for Fibronectin and Laminin in the Avian Embryo".
Pytela et al., 1985, Cell 40:191-198, "Identification and Isolation of a 140 kd Cell Surface Glycoprotein with Properties Expected of a Fibronectin Receptor".
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Rao et al., 1983, Biochem. Biophys. Research Commu. 111:804-809, "Isolation of a Tumor Cell Laminin Receptor".
Lesot et al., 1983, The EMBO Journal 2:861-865, "Isolation of a Laminin-Binding Protein from Muscle Cell Membranes".
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Liotta et al., 1985, Exp. Cell Res. 156:117-126, "Monoclonal Antibodies to the Human Laminin Receptor Recognize Structurally Distinct Sites".
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Barsky et al., 1984, J. Clin. Invest. 74:843-848, "Laminin Molecular Domains with Alter Metastasis in a Murine Model".
Hand et al., 1985, Cancer Research 45:2713-2719, "Expression of Laminin Receptor in Normal and Carcinomatous Human Tissues as Defined by a Monoclonal Antibody".
Young et al., 1983, Proc. Natl. Acad. Sci. U.S.A. 80: 1194-1198, "Efficient Isolation of Genes by Using Antibody Probes".
Young et al., 1983, Science 222: 778-782, "Yeast RNA Polymerase II Genes: Isolation with Antibody Probes".
Drohan William N.
Jaye Michael C.
Liotta Lance A.
Sobel Mark E.
Wewer Ulla M.
Brown Johnnie R.
Jay Jeremy M.
The United States of America as represented by the Department of
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